Subunit vaccines are significantly more expensive to produce than traditional vaccines
because they are based primarily on recombinant proteins that must be purified from the …

ABSTRACT A vaccine to prevent the transmission of malaria parasites from infected humans
to mosquitoes is an important component for the elimination of malaria in the 21st century …

Malaria is a widespread and infectious disease that is a leading cause of death in many
parts of the world. Eradication of malaria has been a major world health goal for decades …

Infectious diseases disproportionately affect indigent regions and are the greatest cause of
childhood mortality in developing countries. Practical, low-cost vaccines for use in these …

Malaria is a leading cause of morbidity and mortality, estimated to cause> 1 million
childhood deaths annually. Plasmodium falciparum causes the most severe form of the …

Transmission-blocking vaccines are based on eliciting antibody responses in the vertebrate
host that disrupt parasite development in the mosquito vector and prevent malaria …

A transmission-blocking vaccine (TBV) against Plasmodium falciparum is likely to be a
valuable tool in a malaria eradication program. Pfs230 is one of the major TBV candidates …

Malaria is a serious and sometimes fatal mosquito-borne disease caused by a protozoan
parasite. Each year, it is estimated that over one million people are killed by malaria, yet the …

Abstract Background Transmission-blocking vaccines (TBVs) have become a focus of
strategies to control and eventually eliminate malaria as they target the entry of sexual stage …

Plasmodium falciparum is transmitted to a new host after completing its sexual cycle within a
mosquito. Developing vaccines against the parasite sexual stages is a critical component in …