Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

In eukaryotes, chromatin remodeling and post-translational modifications (PTMs) shape the
local chromatin landscape to establish permissive and repressive regions within the …

Many chromatin-modifying enzymes require metabolic cofactors to support their catalytic
activities, providing a direct path for fluctuations in metabolite availability to regulate the …

Dynamic regulation of gene expression in response to changing local conditions is critical
for the survival of all organisms. In metazoans, coherent regulation of gene expression …

Chromatin-modifying enzymes have long been proposed to be the authors of an epigenetic
language, but the origin and meaning of the messages they write in chromatin are still …

How cells sense and respond to environmental cues remains a central question of biological
research. Recent evidence suggests that DNA transcription is regulated by chromatin …

The molecular signatures of epigenetic regulation and chromatin architectures are
fundamental to genetically determined biological processes. Covalent and post-translational …

The physiological identity of every cell is maintained by highly specific transcriptional
networks that establish a coherent molecular program that is in tune with nutritional …

The substrates used to modify nucleic acids and chromatin are affected by nutrient
availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a …

Epigenetic modifications on chromatin are most commonly thought to be involved in the
transcriptional regulation of gene expression. Due to their dependency on small-molecule …