The inhibitory regulators, known as immune checkpoints, prevent overreaction of the
immune system, avoid normal tissue damage, and maintain immune homeostasis during the …

The first generation of immune checkpoint inhibitors (ICIs) including anti-CTLA-4 and anti-
PD-1/anti-PD-L1 has achieved profound and great success. Till 2019 Q1, there are nine ICIs …

Finding effective treatments for cancer remains a challenge. Recent studies have found that
the mechanisms of tumor evasion are becoming increasingly diverse, including abnormal …

The expression of immune checkpoint molecules on T cells represents an important
mechanism that the immune system uses to regulate responses to self-proteins. Checkpoint …

Cancer immunotherapy has been a great breakthrough, with immune checkpoint inhibitors
leading the way. Despite the clinical effectiveness of certain immune checkpoint inhibitors …

With the goal of harnessing the host's immune system to provide long-lasting remission and
cures for various cancers, the advent of immunotherapy revolutionized the cancer therapy …

In recent years, the role of cancer immunotherapy has become increasingly important
compared to traditional cancer treatments, including surgery, chemotherapy and …

Immune checkpoints within the tumor microenvironment (TME) play important roles in
modulating host antitumor immunity. Checkpoint-based immunotherapies (eg immune …

Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have
revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory …

Immune checkpoint therapy: Forging ahead | Science Translational Medicine news careers
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