Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

Emerging single-cell epigenomic methods are being developed with the exciting potential to
transform our knowledge of gene regulation. Here we review available techniques and …

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

Epigenomics is the study of the physical modifications, associations and conformations of
genomic DNA sequences, with the aim of linking these with epigenetic memory, cellular …

The human genome contains millions of candidate cis-regulatory elements (CREs) with cell-
type-specific activities that shape both health and myriad disease states. However, we lack a …

Emerging evidence is shedding light on a large and complex network of epigenetic
modifications at play in human stem cells. This “epigenetic landscape” governs the fine …

Genome-wide association studies (GWAS) have linked hundreds of thousands of sequence
variants in the human genome to common traits and diseases. However, translating this …

Epigenetic mechanisms control gene expression in a way that is stably propagated over
multiple cell divisions, but which is also flexible enough to respond to environmental …

Epigenome-wide association studies (EWAS) provide an alternative approach for studying
human disease through consideration of non-genetic variants such as altered DNA …

Epigenetic alterations are associated with normal biological processes such as aging or
differentiation. Changes in global epigenetic signatures, together with genetic alterations …