Genetically engineered live Plasmodium falciparum sporozoites constitute a potential
platform for creating consistently attenuated, genetically defined, whole-parasite vaccines …

Immunization with live-attenuated Plasmodium sporozoites completely protects against
malaria infection. Genetic engineering offers a versatile platform to create live-attenuated …

Immunization of humans with whole sporozoites confers complete, sterilizing immunity
against malaria infection. However, achieving consistent safety while maintaining …

Background Immunization with genetically engineered, attenuated malaria parasites (GAP)
that arrest during liver infection confers sterile protection in mouse malaria models. A first …

Immunization with attenuated Plasmodium sporozoites can induce protection against
malaria infection, as shown by Plasmodium falciparum (Pf) sporozoites attenuated by …

Vaccination with live-attenuated Plasmodium sporozoites that arrest in the liver can
completely protect against a malaria infection both in animal models and in humans; this has …

Falciparum malaria is initiated when Anopheles mosquitoes transmit the Plasmodium
sporozoite stage during a blood meal. Irradiated sporozoites confer sterile protection against …

A live-attenuated malaria vaccine, Plasmodium falciparum sporozoite vaccine (PfSPZ
Vaccine), confers sterile protection against controlled human malaria infection (CHMI) with …

Abstract Immunization with Plasmodium falciparum (Pf) sporozoites under
chemoprophylaxis (PfSPZ-CVac) is the most efficacious approach to malaria vaccination …

Background Sterile protection in> 90% of volunteers against homologous Plasmodium
falciparum infection has been achieved only using the controlled human malaria infection …