Historically, vaccines have been designed to mimic the immunity induced by natural
exposure to the target pathogen, but this approach has not been effective for any parasitic …

Vaccines are one of the most effective interventions to improve public health, however, the
generation of highly effective vaccines for many diseases has remained difficult. Three …

Recent advances in the fields of genomics, proteomics and molecular immunology offer
tremendous opportunities for the development of novel interventions against public health …

Although it is more than a decade since the parasite genome information was obtained,
standardized novel genome-wide selection/prioritization strategies for candidacy of malaria …

The development of vaccines against complex intracellular pathogens, such as Plasmodium
spp., where protection is likely mediated by cellular immune responses, has proven elusive …

Introduction: An efficacious malaria vaccine is necessary to advance the current control
measures towards malaria elimination. To-date, only RTS, S/AS01, a leading pre …

Until recently, malaria vaccine development efforts have focused almost exclusively on a
handful of well characterized Plasmodium falciparum antigens. Despite dedicated work by …

The Plasmodium parasite, the causative agent of malaria, is an excellent model for
immunomic-based approaches to vaccine development. The Plasmodium parasite has a …

Malaria, unlike many diseases, has evolved as a result of millions of years of interactions at
various levels with the mammalian system and hence has found ways to gather resistance to …

Although epidemiological observations, IgG passive transfer studies and experimental
infections in humans all support the feasibility of developing highly effective malaria …