Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

L Fachal, H Aschard, J Beesley, DR Barnes, J Allen… - Nature …, 2020 - nature.com
Genome-wide association studies have identified breast cancer risk variants in over 150
genomic regions, but the mechanisms underlying risk remain largely unknown. These …

[HTML][HTML] eQTL colocalization analyses identify NTN4 as a candidate breast cancer risk gene

J Beesley, H Sivakumaran, MM Marjaneh, W Shi… - The American Journal of …, 2020 - cell.com
Breast cancer genome-wide association studies (GWASs) have identified 150 genomic risk
regions containing more than 13,000 credible causal variants (CCVs). The CCVs are …

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

L Wu, W Shi, J Long, X Guo, K Michailidou, J Beesley… - Nature …, 2018 - nature.com
The breast cancer risk variants identified in genome-wide association studies explain only a
small fraction of the familial relative risk, and the genes responsible for these associations …

[PDF][PDF] A comprehensive cis-eQTL analysis revealed target genes in breast cancer susceptibility loci identified in genome-wide association studies

X Guo, W Lin, J Bao, Q Cai, X Pan, M Bai… - The American Journal of …, 2018 - cell.com
Genome-wide association studies (GWASs) have identified more than 150 common genetic
loci for breast cancer risk. However, the target genes and underlying mechanisms remain …

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

MA Ferreira, ER Gamazon, F Al-Ejeh… - Nature …, 2019 - nature.com
Genome-wide association studies (GWAS) have identified more than 170 breast cancer
susceptibility loci. Here we hypothesize that some risk-associated variants might act in non …

Common genetic variation and breast cancer risk—past, present, and future

J Lilyquist, KJ Ruddy, CM Vachon, FJ Couch - … Epidemiology, Biomarkers & …, 2018 - AACR
Breast cancer is the most common cancer among women in the United States, with up to
30% of those diagnosed displaying a family history of breast cancer. To date, 18% of the …

[HTML][HTML] Inherited genetic susceptibility to breast cancer: the beginning of the end or the end of the beginning?

M Ghoussaini, PDP Pharoah, DF Easton - The American journal of …, 2013 - Elsevier
Genome-wide association studies have identified 72 loci associated with breast cancer
susceptibility. Seventeen of these are known to predispose to other cancers. High …

Capture Hi-C identifies putative target genes at 33 breast cancer risk loci

JS Baxter, OC Leavy, NH Dryden, S Maguire… - Nature …, 2018 - nature.com
Genome-wide association studies (GWAS) have identified approximately 100 breast cancer
risk loci. Translating these findings into a greater understanding of the mechanisms that …

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

K Michailidou, P Hall, A Gonzalez-Neira… - Nature …, 2013 - nature.com
Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

K Michailidou, J Beesley, S Lindstrom, S Canisius… - Nature …, 2015 - nature.com
Genome-wide association studies (GWAS) and large-scale replication studies have
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …