The natural flavonoid pinocembrin: molecular targets and potential therapeutic applications

X Lan, W Wang, Q Li, J Wang - Molecular neurobiology, 2016 - Springer
Pinocembrin is a natural flavonoid compound extracted from honey, propolis, ginger roots,
wild marjoram, and other plants. In preclinical studies, it has shown anti-inflammatory and …

Pinocembrin: a novel natural compound with versatile pharmacological and biological activities

A Rasul, FM Millimouno, W Ali Eltayb… - BioMed research …, 2013 - Wiley Online Library
Pinocembrin (5, 7‐dihydroxyflavanone) is one of the primary flavonoids isolated from the
variety of plants, mainly from Pinus heartwood, Eucalyptus, Populus, Euphorbia, and …

Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion

MA Saad, RM Abdel Salam, SA Kenawy… - Pharmacological …, 2015 - Springer
Background Pinocembrin is a major flavonoid molecule isolated from honey and propolis. It
has versatile pharmacological and biological activities including antimicrobial, anti …

Advances in biosynthesis, pharmacology, and pharmacokinetics of pinocembrin, a promising natural small-molecule drug

X Shen, Y Liu, X Luo, Z Yang - Molecules, 2019 - mdpi.com
Pinocembrin is one of the most abundant flavonoids in propolis, and it may also be widely
found in a variety of plants. In addition to natural extraction, pinocembrin can be obtained by …

[HTML][HTML] Current advances on the therapeutic potential of pinocembrin: an updated review

MH Elbatreek, I Mahdi, W Ouchari, MF Mahmoud… - Biomedicine & …, 2023 - Elsevier
Abstract Pinocembrin (5, 7-dihydroxyflavone) is a major flavonoid found in many plants,
fungi and hive products, mainly honey and propolis. Several in vitro and preclinical studies …

Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia–reperfusion both in vivo and in vitro

R Liu, M Gao, ZH Yang, GH Du - Brain research, 2008 - Elsevier
Pinocembrin is one of the flavonoids at the highest concentration in propolis. In this study,
we investigated the neuroprotective effect of pinocembrin on ischemia/reperfusion and …

Pharmacokinetics, safety, and tolerability of single and multiple-doses of pinocembrin injection administered intravenously in healthy subjects

G Cao, P Ying, B Yan, W Xue, K Li, A Shi, T Sun… - Journal of …, 2015 - Elsevier
Ethnopharmacological relevance Pinocembrin is the most abundant flavonoid in propolis.
Preclinical studies have suggested that pinocembrin protects rat brain against oxidation and …

Pinocembrin protects the neurovascular unit by reducing inflammation and extracellular proteolysis in MCAO rats

M Gao, SY Zhu, CB Tan, B Xu, WC Zhang… - Journal of Asian …, 2010 - Taylor & Francis
The purpose of the present study was to examine the protective action and mechanisms of
pinocembrin (1) on the neurovascular unit (NVU) in permanent cerebral ischemic rats. Focal …

The characteristics of therapeutic effect of pinocembrin in transient global brain ischemia/reperfusion rats

L Shi, B Chen, M Gao, H Zhang, Y Li, L Wang, G Du - Life sciences, 2011 - Elsevier
AIMS: The therapeutic effect of pinocembrin, together with the therapeutic time window, in
the transient global cerebral ischemia/reperfusion (I/R) rats was investigated. MAIN …

[HTML][HTML] Neuroprotective effects of pinocembrin on ischemia/reperfusion-induced brain injury by inhibiting autophagy

J Tao, C Shen, Y Sun, W Chen, G Yan - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Background Cerebral ischemia/reperfusion (I/R) injury is a common pathological process
after cardiac arrest, shock and acute cerebral infarction recanalization, which causes serious …