Alternative splicing of human telomerase reverse transcriptase (hTERT) and its implications in physiological and pathological processes
AA Plyasova, DD Zhdanov - Biomedicines, 2021 - mdpi.com
Alternative splicing (AS) of human telomerase catalytic subunit (hTERT, human telomerase
reverse transcriptase) pre-mRNA strongly regulates telomerase activity. Several proteins …
reverse transcriptase) pre-mRNA strongly regulates telomerase activity. Several proteins …
Alternative splicing of hTERT pre-mRNA: a potential strategy for the regulation of telomerase activity
X Liu, Y Wang, G Chang, F Wang, F Wang… - International journal of …, 2017 - mdpi.com
The activation of telomerase is one of the key events in the malignant transition of cells, and
the expression of human telomerase reverse transcriptase (hTERT) is indispensable in the …
the expression of human telomerase reverse transcriptase (hTERT) is indispensable in the …
Physiological and pathological significance of human telomerase reverse transcriptase splice variants
FM Bollmann - Biochimie, 2013 - Elsevier
Human telomerase reverse transcriptase (hTERT) is tightly regulated at various
transcriptional and post-transcriptional levels. Alternative splicing of hTERT has been shown …
transcriptional and post-transcriptional levels. Alternative splicing of hTERT has been shown …
Alternative splicing of telomerase catalytic subunit hTERT generated by apoptotic endonuclease EndoG induces human CD4+ T cell death
DD Zhdanov, DA Vasina, VA Grachev… - European Journal of …, 2017 - Elsevier
Telomerase activity is regulated by alternative splicing of its catalytic subunit human
Telomerase Reverse Transcriptase (hTERT) mRNA. Induction of a non-active spliced …
Telomerase Reverse Transcriptase (hTERT) mRNA. Induction of a non-active spliced …
Human normal T lymphocytes and lymphoid cell lines do express alternative splicing variants of human telomerase reverse transcriptase (hTERT) mRNA
M Jalink, Z Ge, C Liu, M Björkholm, A Gruber… - … and biophysical research …, 2007 - Elsevier
Alternative splicing of telomerase reverse transcriptase (hTERT) mRNA is known to
contribute to regulation of telomerase activity in normal and cancerous cells, however …
contribute to regulation of telomerase activity in normal and cancerous cells, however …
The Role of Alternative RNA Splicing in the Regulation of hTERT, Telomerase, and Telomeres: Implications for Cancer Therapeutics
Alternative RNA splicing impacts the majority (> 90%) of eukaryotic multi-exon genes,
expanding the coding capacity and regulating the abundance of gene isoforms. Telomerase …
expanding the coding capacity and regulating the abundance of gene isoforms. Telomerase …
Human telomerase reverse transcriptase regulation by DNA methylation, transcription factor binding and alternative splicing
BA Avin, CB Umbricht… - … journal of oncology, 2016 - spandidos-publications.com
The catalytic subunit of telomerase, human telomerase reverse transcriptase (hTERT), plays
an essential role in telomere maintenance to oppose cellular senescence and, is highly …
an essential role in telomere maintenance to oppose cellular senescence and, is highly …
Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA …
S Sæbøe-Larssen, E Fossberg, G Gaudernack - BMC molecular biology, 2006 - Springer
Background Human telomerase reverse transcriptase (hTERT) is a key component for
synthesis and maintenance of telomeres on chromosome ends and is required for the …
synthesis and maintenance of telomeres on chromosome ends and is required for the …
Oligomer-mediated modulation of hTERT alternative splicing induces telomerase inhibition and cell growth decline in human prostate cancer cells
C Brambilla, M Folini, P Gandellini, L Daprai… - Cellular and Molecular …, 2004 - Springer
The expression of telomerase in human cells is strictly controlled by multiple mechanisms
including transcription and alternative splicing of telomerase reverse transcriptase (hTERT) …
including transcription and alternative splicing of telomerase reverse transcriptase (hTERT) …
[HTML][HTML] Expression pattern of alternative splicing variants of human telomerase reverse transcriptase (hTERT) in cancer cell lines was not associated with the origin of …
M Khosravi-Maharlooei, M Jaberipour… - … journal of molecular …, 2015 - ncbi.nlm.nih.gov
Telomerase and systems controlling their activity have been of great attention. There are
controversies regarding the role of the alternative splicing forms of the human telomerase …
controversies regarding the role of the alternative splicing forms of the human telomerase …