Nasal sprays are typically characterized using in vitro spray metrics such as spray cone
angle and droplet size distribution. It is currently not clear how these in vitro metrics correlate …

A mathematical approach was developed to estimate spray deposition patterns in the nasal
cavity based on the geometric relationships between the emitted spray plume and the …

This work describes the development of an idealized geometry that mimics average regional
deposition of nasal sprays within realistic adult nasal geometries. Previous simulation …

This study investigated the intricate dynamics of intranasal spray deposition within nasal
models, considering variations in head orientation and stages of the nasal cycle. Employing …

Large intersubject variability in local drug delivery to the target regions in the nose, the
region posterior to the internal nasal valve (INV), was previously demonstrated in vitro by …

To improve the relationships between commonly conducted in vitro studies for locally-acting
nasal spray drug products with in vivo regional deposition, this study developed a set of in …

Validating numerical models against experimental models of nasal spray deposition is
challenging since many aspects must be considered. That being said, it is a critical step in …

Many studies suggest limited effectiveness of spray devices for nasal drug delivery due
primarily to high deposition and clearance at the front of the nose. Here, nasal spray …

In this study, the effects of nasal drug delivery device and the spray nozzle orientation on
sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior …

In addition to topical delivery, nasal sprays offer an alternative drug administration route to
the systemic circulation, therefore avoiding the need for painful, invasive delivery …