What do we know about the genetic architecture of psychopathology?

EJ Giangrande, RS Weber… - Annual Review of Clinical …, 2022 - annualreviews.org
In the second half of the twentieth century, twin and family studies established beyond a
reasonable doubt that all forms of psychopathology are substantially heritable and highly …

Biological variables in psychopathology: A psychobiological perspective

DC Fowles - Comprehensive handbook of psychopathology, 1993 - Springer
In this chapter, we have reviewed the behavior genetic literature for a number of the major
forms of child and adult psychopathology, including schizophrenia, schizophrenia spectrum …

Psychiatric genetics and the structure of psychopathology

JW Smoller, OA Andreassen, HJ Edenberg… - Molecular …, 2019 - nature.com
For over a century, psychiatric disorders have been defined by expert opinion and clinical
observation. The modern DSM has relied on a consensus of experts to define categorical …

Redefining phenotypes to advance psychiatric genetics: Implications from hierarchical taxonomy of psychopathology.

MA Waszczuk, NR Eaton, RF Krueger… - Journal of abnormal …, 2020 - psycnet.apa.org
Genetic discovery in psychiatry and clinical psychology is hindered by suboptimal
phenotypic definitions. We argue that the hierarchical, dimensional, and data-driven …

Genetics in psychosomatic medicine: research designs and statistical approaches

JM McCaffery, H Snieder, Y Dong… - Psychosomatic …, 2007 - journals.lww.com
It has become increasingly clear that genetic factors influence many of the behaviors and
disease endpoints of interest to psychosomatic medicine researchers. There has been …

Assessing the evidence for shared genetic risks across psychiatric disorders and traits

J Martin, MJ Taylor, P Lichtenstein - Psychological medicine, 2018 - cambridge.org
Genetic influences play a significant role in risk for psychiatric disorders, prompting
numerous endeavors to further understand their underlying genetic architecture. In this …

[图书][B] The behavioral genetics of psychopathology: A clinical guide

KL Jang - 2005 - taylorfrancis.com
New discoveries about the genetic underpinnings of many kinds of human experience are
now continually being made. This book explores the impact of these discoveries on the ways …

Molecular genetics in psychology and personality neuroscience: On candidate genes, genome wide scans, and new research strategies

C Montag, RP Ebstein, P Jawinski, S Markett - … & Biobehavioral Reviews, 2020 - Elsevier
Despite the substantial heritability estimates for psychological traits, their precise genetic
foundation from a molecular perspective remains elusive. We summarize findings and …

Psychiatric genetics: a methodologic critique

KS Kendler - American Journal of Psychiatry, 2005 - Am Psychiatric Assoc
Psychiatric genetics, which is growing in size and influence within psychiatry, employs four
major research paradigms: 1) basic genetic epidemiology, 2) advanced genetic …

Advancing psychiatric genetics through dissecting heterogeneity

K Hodgson, P McGuffin, CM Lewis - Human Molecular Genetics, 2017 - academic.oup.com
There has been substantial progress in psychiatric genetics in recent years, through
collaborative efforts to build large samples sizes for case/control analyses for a number of …