[HTML][HTML] Colchicine and the combination of rivaroxaban and aspirin in patients hospitalised with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial

JW Eikelboom, SS Jolly, EP Belley-Cote… - The Lancet …, 2022 - thelancet.com
Background COVID-19 disease is accompanied by a dysregulated immune response and
hypercoagulability. The Anti-Coronavirus Therapies (ACT) inpatient trial aimed to evaluate …

[HTML][HTML] Colchicine and aspirin in community patients with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial

JW Eikelboom, SS Jolly, EP Belley-Cote… - The Lancet …, 2022 - thelancet.com
Background The large number of patients worldwide infected with the SARS-CoV-2 virus
has overwhelmed health-care systems globally. The Anti-Coronavirus Therapies (ACT) …

[HTML][HTML] Rivaroxaban to prevent major clinical outcomes in non-hospitalised patients with COVID-19: the CARE–COALITION VIII randomised clinical trial

Á Avezum, HAO Junior, PDMM Neves, LBO Alves… - …, 2023 - thelancet.com
Background COVID-19 progression is associated with an increased risk of arterial and
venous thrombosis. Randomised trials have demonstrated that anticoagulants reduce the …

Antithrombotic therapy in patients with COVID-19?-Rationale and Evidence

C Godino, A Scotti, N Maugeri, N Mancini… - International journal of …, 2021 - Elsevier
In patients with severe or critical Coronavirus disease 2019 (COVID-19) manifestations, a
thromboinflammatory syndrome, with diffuse microvascular thrombosis, is increasingly …

[HTML][HTML] Enoxaparin for outpatients with COVID-19: 90-day results from the randomised, open-label, parallel-group, multinational, phase III OVID trial

D Voci, A Götschi, U Held, R Bingisser, G Colucci… - Thrombosis research, 2023 - Elsevier
Introduction The benefits of early thromboprophylaxis in symptomatic COVID-19 outpatients
remain unclear. We present the 90-day results from the randomised, open-label, parallel …

Interleukin-6 receptor blockade with subcutaneous tocilizumab improves coagulation activity in patients with COVID-19

M Di Nisio, N Potere, M Candeloro, A Spacone… - European journal of …, 2021 - Elsevier
Background Many COVID-19 patients develop a hyperinflammatory response which
activates blood coagulation and may contribute to the occurrence of thromboembolic …

Therapeutic versus prophylactic anticoagulation for severe COVID-19: A randomized phase II clinical trial (HESACOVID)

ACB Lemos, DA do Espírito Santo, MC Salvetti… - Thrombosis research, 2020 - Elsevier
Abstract Introduction Coronavirus disease 2019 (COVID-19) causes a hypercoagulable
state. Several autopsy studies have found microthrombi in pulmonary circulation. Methods In …

[HTML][HTML] COVID-19-associated coagulopathy and antithrombotic agents—lessons after 1 year

J Leentjens, TF Van Haaps, PF Wessels… - The Lancet …, 2021 - thelancet.com
COVID-19 is associated with a high incidence of thrombotic complications, which can be
explained by the complex and unique interplay between coronaviruses and endothelial …

Clinical outcomes and the impact of prior oral anticoagulant use in patients with coronavirus disease 2019 admitted to hospitals in the UK—a multicentre observational …

DJ Arachchillage, I Rajakaruna, Z Odho… - British journal of …, 2022 - Wiley Online Library
Coagulation dysfunction and thrombosis are major complications in patients with
coronavirus disease 2019 (COVID‐19). Patients on oral anticoagulants (OAC) prior to …

Randomized clinical trial to evaluate a routine full anticoagulation strategy in patients with coronavirus infection (SARS-CoV2) admitted to hospital: rationale and …

RD Lopes, RHM Furtado, AVS Macedo… - American heart …, 2021 - Elsevier
Background Observational studies have suggested a higher risk of thrombotic events in
patients with coronavirus disease 2019 (COVID-19). Moreover, elevated D-dimer levels …