Background: Intestinal exposure to gliadin leads to zonulin upregulation and consequent
disassembly of intercellular tight junctions and increased intestinal permeability. We aimed …

Background and aims: Despite the progress made in understanding the immunological
aspects of the pathogenesis of coeliac disease (CD), the early steps that allow gliadin to …

Objective. Little is known about the interaction of gliadin with intestinal epithelial cells and
the mechanism (s) through which gliadin crosses the intestinal epithelial barrier. We …

Coeliac disease is a chronic enteropathy caused by the ingestion of wheat gliadin and other
cereal prolamines derived from rye and barley. In the present work, we investigated the …

Background & Aims: Celiac disease is an immune-mediated enteropathy triggered by
gliadin, a component of the grain protein gluten. Gliadin induces an MyD88-dependent …

Intestinal permeability is frequently abnormal in patients with celiac disease. The long-term
effect of a gluten-free diet on intestinal permeability and the correlation of intestinal …

Autoimmune diseases are characterized by tissue damage and loss of function due to an
immune response that is directed against specific organs. This review is focused on celiac …

Background Celiac disease is characterized by enhanced intestinal paracellular
permeability due to alterations of function and expression of tight junction (TJ) proteins …

The intestinal permeability of undegraded α9-gliadin peptide 31-49 (p31-49) and 33-mer
gliadin peptides is increased in active celiac disease. Two distinct transport pathways have …

Background & Aims Nonceliac gluten-sensitive (NCGS) patients report intestinal and extra-
intestinal symptoms shortly after ingesting gluten; these symptoms disappear on gluten-free …