Omicron variant strains encode large numbers of changes in the spike protein compared to
historical SARS-CoV-2 isolates. Although in vitro studies have suggested that several …

Summary Background In recent months, Omicron variants of SARS-CoV-2 have become
dominant in many regions of the world, and case numbers with Omicron subvariants BA. 1 …

Despite the development and deployment of antibody and vaccine countermeasures, rapidly-
spreading SARS-CoV-2 variants with mutations at key antigenic sites in the spike protein …

The recent emergence of SARS-CoV-2 Omicron variants possessing large numbers of
mutations has raised concerns of decreased effectiveness of current vaccines, therapeutic …

Abstract The SARS-CoV-2 Omicron variant has very high levels of transmission, is resistant
to neutralization by authorized therapeutic human monoclonal antibodies (mAb) and is less …

Rapidly emerging SARS-CoV-2 variants jeopardize antibody-based countermeasures.
Although cell culture experiments have demonstrated a loss of potency of several anti-spike …

The new SARS-CoV-2 variant of concern “Omicron” was recently spotted in South Africa and
spread quickly around the world due to its enhanced transmissibility. The variant became …

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
major antigen stimulating the host's protective immune response. Here we assessed the …

SARS-CoV-2 neutralizing antibodies play a critical role in COVID-19 prevention and
treatment but are challenged by viral evolution and the emergence of novel escape variants …

In this study, by characterizing several human monoclonal antibodies (mAbs) isolated from
single B cells of the COVID-19–recovered individuals in India who experienced ancestral …