The impact of chromosomal sex on cardiometabolic health and disease

CB Wiese, R Avetisyan, K Reue - Trends in Endocrinology & Metabolism, 2023 - cell.com
Many aspects of metabolism are sex-biased, from gene expression in metabolic tissues to
the prevalence and presentation of cardiometabolic diseases. The influence of hormones …

Illuminating the mechanisms underlying sex differences in cardiovascular disease

K Reue, CB Wiese - Circulation research, 2022 - Am Heart Assoc
Sex is a key risk factor for many types of cardiovascular disease. It is imperative to
understand the mechanisms underlying sex differences to devise optimal preventive and …

[HTML][HTML] Sex differences in obesity, lipid metabolism, and inflammation—a role for the sex chromosomes?

T Zore, M Palafox, K Reue - Molecular metabolism, 2018 - Elsevier
Background Sex differences in obesity and related diseases are well established. Gonadal
hormones are a major determinant of these sex differences. However, sex differences in …

Sex hormones and sex chromosomes cause sex differences in the development of cardiovascular diseases

AP Arnold, LA Cassis, M Eghbali, K Reue… - … , and vascular biology, 2017 - Am Heart Assoc
This review summarizes recent evidence concerning hormonal and sex chromosome effects
in obesity, atherosclerosis, aneurysms, ischemia/reperfusion injury, and hypertension …

Sex differences in metabolism and cardiometabolic disorders

KC Krishnan, M Mehrabian… - Current opinion in …, 2018 - journals.lww.com
Sex differences in body fat distribution, glucose homeostasis, insulin signaling, ectopic fat
accumulation, and lipid metabolism during normal growth and in response to hormonal or …

Sex differences in obesity: X chromosome dosage as a risk factor for increased food intake, adiposity and co-morbidities

K Reue - Physiology & behavior, 2017 - Elsevier
Obesity is a world-wide problem, and a risk factor for cardiovascular disease, diabetes,
cancer and other diseases. It is well established that sex differences influence fat storage …

The number of x chromosomes causes sex differences in adiposity in mice

X Chen, R McClusky, J Chen, SW Beaven… - PLoS …, 2012 - journals.plos.org
Sexual dimorphism in body weight, fat distribution, and metabolic disease has been
attributed largely to differential effects of male and female gonadal hormones. Here, we …

Epigenetic regulation of autosomal gene expression by sex chromosomes

PJ Wijchers, RJ Festenstein - Trends in genetics, 2011 - cell.com
Males and females display differences in physiology, behaviour and susceptibility to many
diseases. Genome-wide transcription profiling studies have uncovered large-scale sex …

Metabolic impact of sex chromosomes

JC Link, X Chen, AP Arnold, K Reue - Adipocyte, 2013 - Taylor & Francis
Obesity and associated metabolic diseases are sexually dimorphic. To provide better
diagnosis and treatment for both sexes, it is of interest to identify the factors that underlie …

Genetic basis for sex differences in obesity and lipid metabolism

JC Link, K Reue - Annual review of nutrition, 2017 - annualreviews.org
Men and women exhibit significant differences in obesity, cardiovascular disease, and
diabetes. To provide better diagnosis and treatment for both sexes, it is important to identify …