[HTML][HTML] Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's …

HB Dodiya, CB Forsyth, RM Voigt, PA Engen… - Neurobiology of …, 2020 - Elsevier
Recent evidence provides support for involvement of the microbiota-gut-brain axis in
Parkinson's disease (PD) pathogenesis. We propose that a pro-inflammatory intestinal …

Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson's disease

Y Bhattarai, J Si, M Pu, OA Ross, PJ McLean, L Till… - Gut …, 2021 - Taylor & Francis
Parkinson's disease (PD) is a common neurodegenerative disorder characterized primarily
by motor and non-motor gastrointestinal (GI) deficits. GI symptoms' including compromised …

[HTML][HTML] Gut inflammation in association with pathogenesis of Parkinson's disease

QQ Chen, C Haikal, W Li, JY Li - Frontiers in molecular neuroscience, 2019 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disease that is generally thought to be
caused by multiple factors, including environmental and genetic factors. Emerging evidence …

[HTML][HTML] Longitudinal analysis of fecal microbiome and pathologic processes in a rotenone induced mice model of Parkinson's disease

X Yang, Y Qian, S Xu, Y Song, Q Xiao - Frontiers in aging …, 2018 - frontiersin.org
Recent studies reported an association between gut microbiota composition and
Parkinson's disease (PD). However, we know little about the relationship between …

Intestinal pathology and gut microbiota alterations in a methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

F Lai, R Jiang, W Xie, X Liu, Y Tang, H Xiao… - Neurochemical …, 2018 - Springer
Patients with Parkinson's disease (PD) often have non-motor symptoms related to
gastrointestinal (GI) dysfunction, such as constipation and delayed gastric emptying, which …

[HTML][HTML] Gut microenvironmental changes as a potential trigger in Parkinson's disease through the gut–brain axis

SJ Chen, CH Lin - Journal of biomedical science, 2022 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease attributed
to the synergistic effects of genetic risk and environmental stimuli. Although PD is …

[HTML][HTML] The gut-brain axis: is intestinal inflammation a silent driver of Parkinson's disease pathogenesis?

MC Houser, MG Tansey - NPJ Parkinson's disease, 2017 - nature.com
The state of the intestinal environment can have profound effects on the activity of the central
nervous system through the physiological contributions of the microbiota, regulation of …

[HTML][HTML] Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

TR Sampson, JW Debelius, T Thron, S Janssen… - Cell, 2016 - cell.com
The intestinal microbiota influence neurodevelopment, modulate behavior, and contribute to
neurological disorders. However, a functional link between gut bacteria and …

Gut bacterial composition in a mouse model of Parkinson's disease

P Perez-Pardo, HB Dodiya, PA Engen… - Beneficial …, 2018 - wageningenacademic.com
The mechanism of neurodegeneration in Parkinson's disease (PD) remains unknown but it
has been hypothesised that the intestinal tract could be an initiating and contributing factor …

Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson's disease

ME Johnson, A Stringer, L Bobrovskaya - Neurotoxicology, 2018 - Elsevier
While people are often aware of the motor symptoms in Parkinson's disease (PD), few know
of the many non-motor symptoms, which patients report have a greater impact on their …