Background Aging is the strongest risk factor for Parkinson's disease (PD), which is a
clinically heterogeneous movement disorder with highly variable age at onset. DNA …

Background The aim of this study was to assess whether recently identified Parkinson's
disease (PD) risk genes also influence age at onset in PD. Methods We genotyped 23 single …

Background Increasing evidence supports an extensive and complex genetic contribution to
PD. Previous genome‐wide association studies (GWAS) have shed light on the genetic …

Background Age at onset (AAO) is an essential feature of Parkinson's disease (PD) and can
help predict disease progression and mortality. Identification of genetic variants influencing …

Age at onset serves as a predictor of progression and mortality in sporadic Parkinson's
disease (PD). Therefore, the identification of genetic modifiers for age at onset might lead to …

Objectives: A recent study showed that Arab‐Berbers GG homozygous at rs2421947 (C/G)
in the dynamin 3 gene (DNM3) had 12.5 years earlier age at onset of leucine‐rich repeat …

Abstract Background Single nucleotide polymorphisms (SNPs) in the α‐synuclein (SNCA)
gene are associated with differential risk and age at onset (AAO) of both idiopathic and …

Background Parkinson's disease (PD) is a highly age‐related disorder, where common
genetic risk variants affect both disease risk and age at onset. A statistical approach that …

Background Recent genomewide association study meta‐analyses have identified 28 loci
associated with risk of Parkinson's disease (PD). We sought to investigate whether these …

Background: DNA methylation studies in Parkinson's disease (PD) thus far have focused on
disease susceptibility but not progression. Objective: In this epigenome-wide association …