Excessive matrix metalloproteinase-1 and hyperactivation of endothelial cells occurred in COVID-19 patients and were associated with the severity of COVID-19

F Syed, W Li, RF Relich, PM Russell… - The Journal of …, 2021 - academic.oup.com
Background Systemic vascular injury occurs in coronavirus disease 2019 (COVID-19)
patients; however, the underlying mechanisms remain unknown. Methods To clarify the role …

Distinctive biomarker features in the endotheliopathy of COVID-19 and septic syndromes

S Fernández, AB Moreno-Castaño, M Palomo… - Shock, 2022 - journals.lww.com
Background: Endotheliopathy is a key element in COVID-19 pathophysiology, contributing to
both morbidity and mortality. Biomarkers distinguishing different COVID-19 phenotypes from …

Vascular endothelial damage in the pathogenesis of organ injury in severe COVID-19

A Dupont, A Rauch, S Staessens… - … and Vascular Biology, 2021 - Am Heart Assoc
Objective: Whether endotheliopathy only mirrors coronavirus disease 2019 (COVID-19)
severity or plays an intrinsic role in microvascular thrombosis and organ failure remains …

[HTML][HTML] COVID-19 vasculopathy: mounting evidence for an indirect mechanism of endothelial injury

RF Nicosia, G Ligresti, N Caporarello, S Akilesh… - The American journal of …, 2021 - Elsevier
Patients with coronavirus disease 2019 (COVID-19) who are critically ill develop vascular
complications characterized by thrombosis of small, medium, and large vessels. Dysfunction …

Circulating endothelial cells as a marker of endothelial injury in severe COVID-19

C Guervilly, S Burtey, F Sabatier… - The Journal of …, 2020 - academic.oup.com
Beside the commonly described pulmonary expression of the coronavirus disease 2019
(COVID-19), major vascular events have been reported. The objective of this study was to …

Relationship between endothelial and angiogenesis biomarkers envisage mortality in a prospective cohort of COVID-19 patients requiring respiratory support

F Maldonado, D Morales, C Díaz-Papapietro… - Frontiers in …, 2022 - frontiersin.org
Purpose Endothelial damage and angiogenesis are fundamental elements of
neovascularisation and fibrosis observed in patients with coronavirus disease 2019 (COVID …

Markers of endothelial cell activation are associated with the severity of pulmonary disease in COVID-19

WO Osburn, K Smith, L Yanek, N Amat-Alcaron… - PloS one, 2022 - journals.plos.org
Severe coronavirus disease-19 (COVID-19) is characterized by vascular inflammation and
thrombosis. We and others have proposed that the inflammatory response to coronavirus …

Matrix metalloproteinases (MMP) 3 and 9 as biomarkers of severity in COVID-19 patients

M Gelzo, S Cacciapuoti, B Pinchera, A De Rosa… - Scientific Reports, 2022 - nature.com
The molecular basis of the wide clinical heterogeneity of Coronavirus disease 2019 (COVID-
19) is still unknown. Matrix metalloproteinases (MMPs) may have a role in the lung damage …

Evaluation of endothelial dysfunction and inflammatory vasculopathy after SARS-CoV-2 infection—a cross-sectional study

P Jud, P Gressenberger, V Muster, A Avian… - Frontiers in …, 2021 - frontiersin.org
Background: Rising data suggest that COVID-19 affects vascular endothelium while the
underlying mechanisms promoting COVID-19-associated endothelial dysfunction and …

[HTML][HTML] Sustained inflammation, coagulation activation and elevated endothelin-1 levels without macrovascular dysfunction at 3 months after COVID-19

LH Willems, M Nagy, H Ten Cate, HMH Spronk… - Thrombosis research, 2022 - Elsevier
Introduction Endothelial damage and thrombosis caused by COVID-19 may imperil
cardiovascular health. More than a year since the WHO declared COVID-19 pandemic …