[HTML][HTML] m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation
J Li, L Zhu, Y Shi, J Liu, L Lin… - American journal of …, 2019 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) acts as the most common mRNA modification in
mammal cells. Fat Mass and Obesity-associated protein (FTO) is the firstly identified …
mammal cells. Fat Mass and Obesity-associated protein (FTO) is the firstly identified …
m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression
J Liu, D Ren, Z Du, H Wang, H Zhang, Y Jin - Biochemical and biophysical …, 2018 - Elsevier
Abstract N 6-Methyladenosine (m 6 A) represents the most prevalent internal modification in
mammalian mRNAs. Emerging evidences suggest that m 6 A modification is profoundly …
mammalian mRNAs. Emerging evidences suggest that m 6 A modification is profoundly …
[HTML][HTML] FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
The FTO m6A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m6A levels
K Zhu, Y Li, Y Xu - Life Sciences, 2021 - Elsevier
Abstract Aims N6-Methyladenosine (m 6 A) is the most frequent posttranscriptional
modification and plays important roles in tumorigenesis and metastasis. The roles of fat …
modification and plays important roles in tumorigenesis and metastasis. The roles of fat …
[HTML][HTML] RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m6A-YTHDF2 …
Z Tan, S Shi, J Xu, X Liu, Y Lei, B Zhang, J Hua… - Oncogene, 2022 - nature.com
Abstract RNA N6-methyladenosine (m6A) is an emerging regulator of mRNA modifications
and represents a novel player in tumorigenesis. Although it has functional significance in …
and represents a novel player in tumorigenesis. Although it has functional significance in …
[HTML][HTML] A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities
G Xie, XN Wu, Y Ling, Y Rui, D Wu, J Zhou, J Li… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract N 6-methyladenosine (m 6 A) modification is critical for mRNA splicing, nuclear
export, stability and translation. Fat mass and obesity-associated protein (FTO), the first …
export, stability and translation. Fat mass and obesity-associated protein (FTO), the first …
[HTML][HTML] N6-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1
D Wang, X Qu, W Lu, Y Wang, Y Jin, K Hou… - Frontiers in …, 2021 - frontiersin.org
Abnormal RNA m6A methylation is known to lead to the occurrence and progression of
multiple cancers including gastric cancer (GC). However, the integrative effects of all m6A …
multiple cancers including gastric cancer (GC). However, the integrative effects of all m6A …
The potential role of N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene (FTO) in human cancers
J Wang, L Chen, P Qiang - OncoTargets and therapy, 2020 - Taylor & Francis
Abstract N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene
(FTO), previously recognized to be related with obesity and diabetes, was gradually …
(FTO), previously recognized to be related with obesity and diabetes, was gradually …
[HTML][HTML] FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner
J Huang, W Sun, Z Wang, C Lv, T Zhang… - Journal of Experimental …, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) modification is the most common chemical
modification in mammalian mRNAs, and it plays important roles by regulating several …
modification in mammalian mRNAs, and it plays important roles by regulating several …
Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression
JL Chen, B Du - Journal of cancer research and clinical oncology, 2019 - Springer
Purpose The fat mass-and obesity-associated (FTO) gene on chromosome 16q12. 2 shows
an intimate association with obesity and body mass index. Recently, research into the FTO …
an intimate association with obesity and body mass index. Recently, research into the FTO …