Mineralocorticoid receptor (MR) and its ligand aldosterone play a central role in controlling
blood pressure by promoting sodium reabsorption in the kidney. Coregulators are recruited …

LSD1 (lysine-specific demethylase-1) is an epigenetic regulator of gene transcription. LSD1
risk allele in humans and LSD1 deficiency (LSD1+/−) in mice confer increasing salt …

Background Hypertension (HTN) represents a complex heritable disease in which
environmental factors may directly affect gene function via epigenetic mechanisms. The aim …

The impaired capacity of the kidney to excrete sodium plays an essential role in the
development of hypertension. Adrenal corticosteroids control renal handling of sodium by …

Background: MR (mineralocorticoid receptor) antagonists are recommended for patients
with resistant hypertension even when circulating aldosterone levels are not high. Although …

Human risk allele carriers of Lysine-Specific Demethylase 1 (LSD1) and LSD1 deficient
mice have salt sensitive hypertension for unclear reasons. We hypothesized that LSD1 …

Biologic sex influences the development of cardiovascular disease and modifies
aldosterone (ALDO) and blood pressure (BP) phenotypes: females secrete more ALDO, and …

The kidney has a central role in long-term control of blood pressure, and decreased kidney
function is a common but difficult-to-treat cause of hypertension. Conversely, elevated blood …

Excess aldosterone is an important contributor to hypertension and cardiovascular disease.
Conversely, low circulating aldosterone causes salt wasting and hypotension. Aldosterone …

Background and objective Mineralocorticoid receptor (MR) is a member of nuclear receptor
family proteins and contributes to fluid homeostasis in the kidney. Although aldosterone-MR …