Cellular senescence is a complex process involving a close-to-irreversible arrest of the cell
cycle, the acquisition of the senescence-associated secretory phenotype (SASP), as well as …

The progression of physiological ageing is driven by intracellular aberrations including
telomere attrition, genomic instability, epigenetic alterations and loss of proteostasis. These …

With aging, there is increased dysfunction of both innate and adaptive immune responses,
which contributes to impaired immune responses to pathogens and greater mortality and …

Aging is a progressive degenerative process involving a chronic low-grade inflammation
and the accumulation of senescent cells. One major issue is to reveal the mechanisms …

Ageing decreases the function of the immune system and increases susceptibility to some
chronic, infectious, and autoimmune diseases. Senescence cells, which produce …

Immunological aging is strongly associated with the observable deleterious effects of human
aging. Our understanding of the causes, effects, and therapeutics of aging immune cells has …

Senescent cells are generally characterized by permanent cell cycle arrest, metabolic
alteration and activation, and apoptotic resistance in multiple organs due to various …

In response to persistent DNA damage, induction into cell senescence promotes an
immunogenic program which facilitates immune clearance of these damaged cells. Under …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

Infections, cancer and autoimmune diseases occur more frequently in the elderly, and
although many factors contribute to this, the age-related remodelling of the immune system …