The genetic disease Gitelman syndrome, knockout mice, and pharmacological blockade
with thiazide diuretics have revealed that reduced activity of the NaCl cotransporter (NCC) …

Hypomagnesaemia is a common feature of renal Na+ wasting disorders such as Gitelman
and EAST/SeSAME syndrome. These genetic defects specifically affect Na+ reabsorption in …

The renal distal convoluted tubule (DCT) has an essential role in maintaining systemic
magnesium (Mg 2+) concentration. The DCT is the final determinant of plasma Mg 2+ levels …

Background Loss-of-function mutations in the sodium chloride (NaCl) co-transporter (NCC)
of the renal distal convoluted tubule (DCT) cause Gitelman syndrome with hypokalemic …

Thiazide diuretics enhance renal Na+ excretion by blocking the Na+-Cl–cotransporter
(NCC), and mutations in NCC result in Gitelman syndrome. The mechanisms underlying the …

Gitelman's syndrome, an autosomal recessive renal tubulopathy caused by loss-of-function
mutations in the thiazide-sensitive NaCl co-transporter (NCC) of the distal convoluted tubule …

Gitelman syndrome (GS) is characterized by salt‐losing hypotension, hypomagnesemia,
hypokalemic metabolic alkalosis, and hypocalciuria. To better model human GS caused by a …

Mutations in the gene encoding the thiazide-sensitive Na+-Cl− cotransporter (NCC) of the
distal convoluted tubule cause Gitelman's syndrome, an inherited hypokalemic alkalosis …

Mg2+ is essential for many cellular and physiological processes, including muscle
contraction, neuronal activity, and metabolism. Consequently, the blood Mg2+ concentration …

The distal convoluted tubule (DCT) is the shortest segment of the nephron and consists of an
early (DCT1) and late part (DCT2). Here, several transport proteins, like the thiazide …