The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

Proper regulation of gene expression is essential for the differentiation, development and
survival of all cells and organisms. Recent work demonstrates that transcription of many …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Recent advances in sequencing techniques that measure nascent transcripts and that
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …

Recent years have witnessed a sea change in our understanding of transcription regulation:
whereas traditional models focused solely on the events that brought RNA polymerase II …

The rapid expansion of genomics methods has enabled developmental biologists to
address fundamental questions of developmental gene regulation on a genome-wide scale …

A number of proteins and drugs have been implicated in the process of transcriptional
elongation by RNA polymerase (Pol) II, but the factors that govern the elongation rate …

Precise spatio–temporal control of gene activity is essential for organismal development,
growth, and survival in a changing environment. Decisive steps in gene regulation involve …

Elongation factor Paf1C regulates several stages of the RNA polymerase II (Pol II)
transcription cycle, although it is unclear how it modulates Pol II distribution and progression …

Over the past few years, biochemical and genetic studies have shed considerable light on
the structure and function of the RNA polymerase II (pol II) elongation complex and the …