Identification of bona fide tumor suppressors is often challenging because of the large
number of genetic alterations present in most human cancers. To evaluate candidate genes …

The scaffold protein IQGAP1 integrates signaling pathways and participates in diverse
cellular activities. IQGAP1 is overexpressed in a number of human solid neoplasms, but its …

Activation of the WASF3 protein by extracellular stimuli promotes actin cytoskeleton
reorganization and facilitates cancer cell invasion, whereas WASF3 depletion suppresses …

Background Tumor cells exhibit abnormal actin remodeling profiles, which involve the
altered expressions of several important actin-binding proteins. Profilin1 (Pfn1), originally …

Clear-cell renal cell carcinoma (ccRCC), the most common subtype of renal cancer, has a
poor clinical outcome. A hallmark of ccRCC is genetic loss-of-function of VHL (von Hippel …

IQGAP1 is a scaffolding protein that can regulate several distinct signaling pathways. The
accumulating evidence has demonstrated that IQGAP1 plays an important role in …

Profilin-1 (Pfn1) is a ubiquitously expressed actin-monomer binding protein that has been
linked to many cellular activities ranging from control of actin polymerization to gene …

IQGAP1 is a key mediator of several distinct cellular processes, in particular cytoskeletal
rearrangements. Recent studies have implicated a potential role for IQGAP1 in cancer …

Purpose: CLIC4, a member of a family of intracellular chloride channels, is regulated by p53,
c-Myc, and tumor necrosis factor-α. Regulation by factors involved in cancer pathogenesis …

Hypoxia is a common feature of solid tumours that promotes invasion and metastatic
dissemination. Invadopodia are actin-rich membrane protrusions that direct extracellular …