Propolis Has an Anticancer Effect on Early Stage Colorectal Cancer by Affecting Epithelial Differentiation and Gut Immunity in the Tumor Microenvironment

MH Shen, CY Liu, KW Chang, CL Lai, SC Chang… - Nutrients, 2023 - mdpi.com
Colorectal cancer (CRC) is one of the most common cancers and is the second leading
cause of cancer-related death in the world. Due to the westernization of diets, young patients …

The role of propolis as a natural product with potential gastric cancer treatment properties: A systematic review

N Rivera-Yañez, PA Ruiz-Hurtado, CR Rivera-Yañez… - Foods, 2023 - mdpi.com
Gastric cancer is one of the most common, aggressive, and invasive types of malignant
neoplasia. It ranks fifth for incidence and fourth for prevalence worldwide. Products of natural …

Co-administration of 5FU and propolis on AOM/DSS induced colorectal cancer in BALB-c mice

HR Sameni, S Yosefi, M Alipour, A Pakdel… - Life sciences, 2021 - Elsevier
Aims Currently, the main problems with chemotherapy are its side effects, toxicity, and drug
resistance. Propolis has biological activities, such as anti-inflammatory and anti-cancer …

Growth inhibitory activity of ethanol extracts of Chinese and Brazilian propolis in four human colon carcinoma cell lines

M Ishihara, K Naoi, M Hashita, Y Itoh… - Oncology …, 2009 - spandidos-publications.com
More than 300 bio-active compounds have been identified from bee propolis in various
regions of the world. The objective of this study was to examine whether the ethanol extracts …

[HTML][HTML] Chemopreventive and chemotherapeutic effect of propolis and its constituents: a mini-review

HF Chiu, YC Han, YC Shen… - Journal of Cancer …, 2020 - ncbi.nlm.nih.gov
Propolis is a bee wax rich in various phytocomponents and traditionally used to treat various
ailments. Propolis is reported to possess an array of biological properties including anti …

A pilot, randomized, placebo-controlled, double-blind phase 0/biomarker study on effect of artepillin C–rich extract of Brazilian propolis in frequent colorectal adenoma …

H Ishikawa, M Goto, N Matsuura… - Journal of the …, 2012 - Taylor & Francis
Objective: Brazilian propolis, a folk medicine, is used worldwide as an alternative medicine
to prevent colon cancer. The objective of the study was to test in a small pilot biomarker …

Emerging adjuvant therapy for cancer: propolis and its constituents

S Patel - Journal of dietary supplements, 2016 - Taylor & Francis
Propolis is a bee-metabolized resinous substance (bee glue) from plant sap and gums. It
has been in usage as a healing agent since antiquity, yet has not garnered global popularity …

Propolis Enhances 5‐Fluorouracil Mediated Antitumor Efficacy and Reduces Side Effects in Colorectal Cancer: An in Vitro and in Vivo Study

A Kocyigit, EM Guler, E Durmus… - Chemistry & …, 2023 - Wiley Online Library
In this study, we investigated the combined treatment of 5‐fluorouracil (5‐FU) and Anatolian
propolis extract (PE) on colorectal cancer (CRC) using in vitro and in vivo studies. We …

Polyphenol-rich propolis extracts strengthen intestinal barrier function by activating AMPK and ERK signaling

K Wang, X Jin, Y Chen, Z Song, X Jiang, F Hu… - Nutrients, 2016 - mdpi.com
Propolis has abundant polyphenolic constituents and is used widely as a health/functional
food. Here, we investigated the effects of polyphenol-rich propolis extracts (PPE) on …

Cuban brown propolis interferes in the crosstalk between colorectal cancer cells and M2 macrophages

Y Frión-Herrera, D Gabbia, M Scaffidi, L Zagni… - Nutrients, 2020 - mdpi.com
Tumor-associated macrophages (TAMs), primarily the M2 phenotype, are involved in the
progression and metastasis of colorectal cancer (CRC). Cuban brown propolis (Cp) and its …