[HTML][HTML] Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal
Summary N 6-methyladenosine (m 6 A) is an abundant modification in eukaryotic mRNA,
regulating mRNA dynamics by influencing mRNA stability, splicing, export, and translation …
regulating mRNA dynamics by influencing mRNA stability, splicing, export, and translation …
[HTML][HTML] m6A RNA modification controls cell fate transition in mammalian embryonic stem cells
Summary N6-methyl-adenosine (m 6 A) is the most abundant modification on messenger
RNAs and is linked to human diseases, but its functions in mammalian development are …
RNAs and is linked to human diseases, but its functions in mammalian development are …
The 18S rRNA m6A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation
RNA modifications represent a novel layer of regulation of gene expression. Functional
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays …
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays …
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition
Y Wu, X Xu, M Qi, C Chen, M Li, R Yan, X Kou… - Nature cell …, 2022 - nature.com
Abstract N 6-methyladenosine (m6A) and its regulatory components play critical roles in
various developmental processes in mammals. However, the landscape and function of …
various developmental processes in mammals. However, the landscape and function of …
[HTML][HTML] scm6A-seq reveals single-cell landscapes of the dynamic m6A during oocyte maturation and early embryonic development
H Yao, CC Gao, D Zhang, J Xu, G Song, X Fan… - Nature …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) has been demonstrated to regulate RNA metabolism
and various biological processes, including gametogenesis and embryogenesis. However …
and various biological processes, including gametogenesis and embryogenesis. However …
[HTML][HTML] Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
X Liu, H Wang, X Zhao, Q Luo, Q Wang, K Tan… - Nature …, 2021 - nature.com
Abstract RNA N 6-methyladenosine (m6A), the most abundant internal modification of
mRNAs, plays key roles in human development and health. Post-translational methylation of …
mRNAs, plays key roles in human development and health. Post-translational methylation of …
[HTML][HTML] Roles of N6-Methyladenosine (m6A) in Stem Cell Fate Decisions and Early Embryonic Development in Mammals
N6-methyladenosine (m6A) is one of the most abundant internal mRNA modifications, and it
affects multiple biological processes related to eukaryotic mRNA. The majority of m6A sites …
affects multiple biological processes related to eukaryotic mRNA. The majority of m6A sites …
[HTML][HTML] Stabilization of ERK-phosphorylated METTL3 by USP5 increases m6A methylation
Summary N 6-methyladenosine (m 6 A) is the most abundant mRNA modification and is
installed by the METTL3-METTL14-WTAP methyltransferase complex. Although the …
installed by the METTL3-METTL14-WTAP methyltransferase complex. Although the …
METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity
METTL3 and METTL14 are two components that form the core heterodimer of the main RNA
m6A methyltransferase complex (MTC) that installs m6A. Surprisingly, depletion of METTL3 …
m6A methyltransferase complex (MTC) that installs m6A. Surprisingly, depletion of METTL3 …
[HTML][HTML] m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency
Summary N 6-methyladenosine (m 6 A) has been recently identified as a conserved
epitranscriptomic modification of eukaryotic mRNAs, but its features, regulatory mechanisms …
epitranscriptomic modification of eukaryotic mRNAs, but its features, regulatory mechanisms …