[HTML][HTML] Glucagon-like peptide-1 class drugs show clear protective effects in Parkinson's and Alzheimer's disease clinical trials: A revolution in the making?

C Hölscher - Neuropharmacology, 2024 - Elsevier
Parkinson's disease (PD) is a complex syndrome for which there is no disease-modifying
treatment on the market. However, a group of drugs from the Glucagon-like peptide-1 (GLP …

Neuroprotective actions of glucagon-like peptide-1 (GLP-1) analogues in Alzheimer's and Parkinson's diseases

AF Batista, V Bodart-Santos, FG De Felice, ST Ferreira - CNS drugs, 2019 - Springer
The current absence of effective treatments for Alzheimer's disease (AD) and Parkinson's
disease (PD) reflects an incomplete knowledge of the underlying disease processes …

The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review

N Reich, C Hölscher - Frontiers in neuroscience, 2022 - frontiersin.org
Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

[HTML][HTML] The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action

D Athauda, T Foltynie - Drug discovery today, 2016 - Elsevier
Highlights•GLP-1 analogs can cross the blood–brain barrier and stimulate the GLP-1
receptor in the brain.•Stimulation of the GLP-1 receptor has shown effects on mitochondrial …

[HTML][HTML] Clinical Trial Highlights–GLP-1 agonists

K McFarthing, D Larson, T Simuni - Journal of Parkinson's disease, 2020 - ncbi.nlm.nih.gov
Parkinson's Disease (PD) is a heterogeneous, long-term neurodegenerative condition, for
which there are no therapies proven to slow or stop progression. At the same time …

Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases

SD Chen, YC Chuang, TK Lin, JL Yang - European journal of …, 2023 - Elsevier
Aging is a crucial risk factor for common neurodegenerative diseases, such as Alzheimer's
disease (AD) and Parkinson's disease (PD). Limited options are available for the treatment …

Drugs developed for treatment of diabetes show protective effects in Alzheimer's and Parkinson's diseases.

C Hölscher - Sheng li xue bao:[Acta physiologica Sinica], 2014 - europepmc.org
Type 2 diabetes has been identified as a risk factor for Alzheimer's disease (AD) and
Parkinson's disease (PD). In the brains of patients with AD and PD, insulin signaling is …

Glucagon-like peptide-1 (GLP-1) mimetics: a new treatment for Alzheimer's disease?

N García-Casares, JA García-Arnés… - Revista de …, 2014 - europepmc.org
Conclusion The GLP-1 analogs have neuroprotective properties. Considering that type 2
diabetes is a risk factor for cognitive impairment and dementia, the benefits of GLP-1 …

Neuroprotective properties of GLP-1: theoretical and practical applications

JJ Holst, R Burcelin, E Nathanson - Current medical research and …, 2011 - Taylor & Francis
In the past few years, the development of pharmaceutical agents that enhance the
physiological effects of glucagon-like peptide-1 (GLP-1), either through GLP-1 receptor …

GLP-1 receptor agonists: a New Treatment in Parkinson's Disease

K Kalinderi, V Papaliagkas, L Fidani - International Journal of Molecular …, 2024 - mdpi.com
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Recent
data highlight similarities between neurodegenerative diseases, including PD and type 2 …