Multivariate BWAS can be replicable with moderate sample sizes

T Spisak, U Bingel, TD Wager - Nature, 2023 - nature.com
Brain-wide association studies (BWAS)—which correlate individual differences in
phenotypic traits with measures of brain structure and function—have become a dominant …

Reproducible brain-wide association studies require thousands of individuals

S Marek, B Tervo-Clemmens, FJ Calabro, DF Montez… - Nature, 2022 - nature.com
Magnetic resonance imaging (MRI) has transformed our understanding of the human brain
through well-replicated mapping of abilities to specific structures (for example, lesion …

Genome-wide association study identifies 74 loci associated with educational attainment

A Okbay, JP Beauchamp, MA Fontana, JJ Lee, TH Pers… - Nature, 2016 - nature.com
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1 …

Genetic analyses of diverse populations improves discovery for complex traits

GL Wojcik, M Graff, KK Nishimura, R Tao, J Haessler… - Nature, 2019 - nature.com
Genome-wide association studies (GWAS) have laid the foundation for investigations into
the biology of complex traits, drug development and clinical guidelines. However, the …

The African genome variation project shapes medical genetics in Africa

D Gurdasani, T Carstensen, F Tekola-Ayele, L Pagani… - Nature, 2015 - nature.com
Given the importance of Africa to studies of human origins and disease susceptibility,
detailed characterization of African genetic diversity is needed. The African Genome …

Abundant associations with gene expression complicate GWAS follow-up

B Liu, MJ Gloudemans, AS Rao, E Ingelsson… - Nature …, 2019 - nature.com
To the Editor—Genome-wide association studies (GWAS) are rapidly expanding the catalog
of trait-and disease-associated variants. With increasing cohort size and phenotyping …

Genes, brain and cognition

R Plomin, SM Kosslyn - Nature neuroscience, 2001 - nature.com
Genes, brain and cognition | Nature Neuroscience Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Brain–phenotype models fail for individuals who defy sample stereotypes

AS Greene, X Shen, S Noble, C Horien, CA Hahn… - Nature, 2022 - nature.com
Individual differences in brain functional organization track a range of traits, symptoms and
behaviours,,,,,,,,,,–. So far, work modelling linear brain–phenotype relationships has …

[HTML][HTML] Genome-wide association studies of brain imaging phenotypes in UK Biobank

LT Elliott, K Sharp, F Alfaro-Almagro, S Shi, KL Miller… - Nature, 2018 - nature.com
The genetic architecture of brain structure and function is largely unknown. To investigate
this, we carried out genome-wide association studies of 3,144 functional and structural brain …

Large-scale plasma proteomics comparisons through genetics and disease associations

GH Eldjarn, E Ferkingstad, SH Lund, H Helgason… - Nature, 2023 - nature.com
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …