Objectives: To investigate any gender effect of the beta-1 adrenergic blocker, landiolol, on
cardiac performance and energy metabolism in septic rats, and to explore the expression of …

Objectives The aims of this study are to better understand phenotypic differences between
male and female rats during sepsis, to characterise the contribution of the beta1-adrenergic …

Objective: Preliminary experimental data suggest that selective β1-blockers may improve ex
vivo cardiac function in animal sepsis. Currently, the effects of esmolol on in vivo cardiac …

Objective: Since β-blocker therapy is known to be effective in patients with an injured heart,
such as infarction, we designed the present study to examine the protective effects of …

Although epidemiologic research has demonstrated significant differences in incidence and
outcomes of sepsis according to sex, their underlying biological mechanisms are poorly …

Objective: To explore the hypothesis that beta-1 adrenoreceptor blockade may be protective
through the attenuation of sympathetic hyperactivity and catecholaminergic inflammatory …

AIM OF THE STUDY: Adrenergic immuno-modulation mediated by β-adrenergic receptors
has been demonstrated. Pharmacological blockade of β-adrenergic receptors is a …

Development of cardiac dysfunction is associated with increased morbidity and mortality in
patients with sepsis. Increasing evidence shows that gender determines the degree of …

Objectives: Cardiac depression is a well-described manifestation of the sepsis syndrome. An
important underlying mechanism is the attenuation of the adrenergic response at the …

Purpose To present the potential mechanisms by which landiolol enhances a positive
inotropic response in critically ill patients. Methods Analysis of preclinical, animal, and …