Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season

CM Andrade, H Fleckenstein, R Thomson-Luque… - Nature Medicine, 2020 - nature.com
The dry season is a major challenge for Plasmodium falciparum parasites in many malaria
endemic regions, where water availability limits mosquito vectors to only part of the year …

The prevalence of Plasmodium falciparum in sub-Saharan Africa since 1900

RW Snow, B Sartorius, D Kyalo, J Maina, P Amratia… - Nature, 2017 - nature.com
Malaria transmission is influenced by climate, land use and deliberate interventions. Recent
declines have been observed in malaria transmission. Here we show that the African …

Quantitative imaging of Plasmodium transmission from mosquito to mammal

R Amino, S Thiberge, B Martin, S Celli, S Shorte… - Nature medicine, 2006 - nature.com
Plasmodium, the parasite that causes malaria, is transmitted by a mosquito into the dermis
and must reach the liver before infecting erythrocytes and causing disease. We present here …

The selection landscape of malaria parasites

MJ Mackinnon, K Marsh - Science, 2010 - science.org
Malaria parasites have to survive and transmit within a highly selective and ever-changing
host environment. Because immunity to malaria is nonsterilizing and builds up slowly …

An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum

LM Smith, FC Motta, G Chopra, JK Moch, RR Nerem… - Science, 2020 - science.org
The blood stage of the infection of the malaria parasite Plasmodium falciparum exhibits a 48-
hour developmental cycle that culminates in the synchronous release of parasites from red …

Cytoadhesion of Plasmodium falciparum ring-stage-infected erythrocytes

B Pouvelle, PA Buffet, C Lepolard, A Scherf, J Gysin - Nature medicine, 2000 - nature.com
A common pathological characteristic of Plasmodium falciparum infection is the
cytoadhesion of mature-stage-infected erythrocytes (IE) to host endothelium and …

The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015

S Bhatt, DJ Weiss, E Cameron, D Bisanzio, B Mappin… - Nature, 2015 - nature.com
Since the year 2000, a concerted campaign against malaria has led to unprecedented levels
of intervention coverage across sub-Saharan Africa. Understanding the effect of this control …

The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle

VM Howick, AJC Russell, T Andrews, H Heaton… - Science, 2019 - science.org
INTRODUCTION Plasmodium parasites, the causative agent of malaria, are single-celled
organisms with distinct morphological developmental stages each specialized to inhabit …

Host-mediated regulation of superinfection in malaria

S Portugal, C Carret, M Recker, AE Armitage… - Nature medicine, 2011 - nature.com
In regions of high rates of malaria transmission, mosquitoes repeatedly transmit liver-tropic
Plasmodium sporozoites to individuals who already have blood-stage parasitemia. This …

Adaptation of Plasmodium falciparum to its transmission environment

MK Rono, MA Nyonda, JJ Simam, JM Ngoi… - Nature ecology & …, 2018 - nature.com
Success in eliminating malaria will depend on whether parasite evolution outpaces control
efforts. Here, we show that Plasmodium falciparum parasites (the deadliest of the species …