Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a
great threat to global public health since 2020. Although the advance on vaccine …

NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting
innate immune responses. The deleterious effects of inflammasome activation have been …

Novel coronaviruses (nCoVs) encode ion-channel proteins called viroporins such as protein
E, open reading frame 3a (ORF3a) and ORF8a. These viroporins, via mechanisms such as …

Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …

Severe SARS-CoV-2 infection causes systemic inflammation, cytokine storm, and
hypercytokinemia due to activation of the release of pro-inflammatory cytokines that have …

Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with
severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

SARS-CoV-2 might directly activate NLRP3 inflammasome resulting in an endogenous
adjuvant activity necessary to mount a proper adaptive immune response against the virus …

Despite the initial success of some drugs and vaccines targeting COVID-19, understanding
the mechanism underlying SARS-CoV-2 disease pathogenesis remains crucial for the …