Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

After an acute myocardial infarction (AMI), early reperfusion by thrombolysis or primary
percutaneous coronary intervention remains the most-effective strategy for limiting the size …

Brief transient episodes of nonlethal myocardial ischemia protect or “precondition” the heart
and render the myocardium resistant to a subsequent more sustained ischemic insult. The …

Despite nearly twenty years of research into the field of ischemic preconditioning, the actual
mechanism of protection remains unclear. However, much progress has been made in …

Since its first description by Murry et al.(1986) ischaemic preconditioning of the myocardium
has come to be acknowledged as the most consistently powerful and reproducible method …

CORONARY HEART DISEASE is the leading cause of death in the Western world and
represents one of the major burdens on healthcare systems today. Targeting those …

Despite current optimal treatment, the morbidity and mortality of coronary heart disease
(CHD), the leading cause of death worldwide, remains significant, paving the way for the …

The protection conferred by ischemic preconditioning (PC) of myocardium occurs in a
bimodal time course. The early cardioprotection wanes rapidly and is succeeded by a …

Preconditioning the myocardium using short episodes of sublethal ischaemia will delay the
onset of necrosis during a subsequent lethal ischaemic insult. This powerful protective …

Reperfusion injury is a complex process involving several cell types (endothelial cells,
neutrophils, and cardiomyocytes), soluble proinflammatory mediators, oxidants, ionic and …