Simple Summary The coupling of metabolism with cellular status is critically important and
highly evolutionarily conserved. However, how cells coordinate metabolism with …

The altered metabolic programme of cancer cells facilitates their cell-autonomous
proliferation and survival. In normal cells, signal transduction pathways control core cellular …

Long-lived somatic stem cells regenerate adult tissues throughout our lifetime. However,
with aging, there is a significant deterioration in the function of stem and progenitor cells …

Background: The ancient and highly evolutionarily conserved Wnt signaling pathway is
critical in nearly all tissues and organs for an organism to develop normally from embryo …

Simple Summary Given their high degree of identity and even greater similarity at the amino
acid level, Kat3 coactivators, CBP (Kat3A) and p300 (Kat3B), have long been considered …

Oncogenic signaling involved in tumor metabolic reprogramming. Tumorigenesis was not
only determined by the mutations or deletion of oncogenes but also accompanied by the …

Cancer initiation and progression have been attributed to newly discovered subpopulations
of self‐renewing, highly tumorigenic, drug‐resistant tumor cells termed cancer stem cells …

Wnt signaling in stem cells plays critical roles in development, normal adult physiology, and
disease. In this chapter, we focus on the role of the Wnt signaling pathway in somatic stem …

Over 400 million years ago, the evolution of vertebrates gave rise to a life cycle in which the
organism began to live longer particularly as an adult. To accommodate such a longer …

The M2 isoform of pyruvate kinase, highly expressed in tumor cells, is known to engage a
feed forward loop with the glycolysis master transcription factor HIF-1α. Gao and co-authors …