During the early stages of human large ribosomal subunit (60 S) biogenesis, an ensemble of
assembly factors establishes and fine-tunes the essential RNA functional centers of pre-60 S …

The formation of eukaryotic ribosomal subunits extends from the nucleolus to the cytoplasm
and entails hundreds of assembly factors. Despite differences in the pathways of ribosome …

The 90 S preribosome is a large, early assembly intermediate of small ribosomal subunits
that undergoes structural changes to give a pre-40 S ribosome. Here, we gained insight into …

Production of small ribosomal subunits initially requires the formation of a 90 S precursor
followed by an enigmatic process of restructuring into the primordial pre-40 S subunit. We …

Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and∼ 50 ribosomal
proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of …

Early co-transcriptional events during eukaryotic ribosome assembly result in the formation
of precursors of the small (40S) and large (60S) ribosomal subunits. A multitude of transient …

INTRODUCTION The ribosome catalyzes protein synthesis in all cells by coupling the
decoding of messenger RNA by the small ribosomal subunit with peptide bond formation by …

Ribosome biogenesis is a highly complex process in eukaryotes, involving temporally and
spatially regulated ribosomal protein (r-protein) binding and ribosomal RNA remodelling …

Eukaryotic ribosomes, the protein-producing factories of the cell, are composed of four
ribosomal RNA molecules and roughly 80 proteins. Their biogenesis is a complex process …

Four decades after early in vitro assembly studies demonstrated that ribosome assembly is a
controlled process, our understanding of ribosome assembly is still incomplete. Just as …