S-Adenosylmethionine: more than just a methyl donor
Covering: from 2000 up to the very early part of 2023 S-Adenosyl-L-methionine (SAM) is a
naturally occurring trialkyl sulfonium molecule that is typically associated with biological …
naturally occurring trialkyl sulfonium molecule that is typically associated with biological …
S-adenosylmethionine: nothing goes to waste
M Fontecave, M Atta, E Mulliez - Trends in biochemical sciences, 2004 - cell.com
S-adenosylmethionine (SAM or AdoMet) is a biological sulfonium compound known as the
major biological methyl donor in reactions catalyzed by methyltransferases. SAM is also …
major biological methyl donor in reactions catalyzed by methyltransferases. SAM is also …
Spontaneous Emergence of S‐Adenosylmethionine and the Evolution of Methylation
S‐Adenosylmethionine (SAM) is an essential methylation cofactor. The origins of SAM
methylation are complex, seemingly demanding the simultaneous emergence of an enzyme …
methylation are complex, seemingly demanding the simultaneous emergence of an enzyme …
Large-Scale, Protection-Free Synthesis of Se-Adenosyl-l-selenomethionine Analogues and Their Application as Cofactor Surrogates of Methyltransferases
IR Bothwell, M Luo - Organic letters, 2014 - ACS Publications
S-Adenosyl-l-methionine (SAM) analogues have previously demonstrated their utility as
chemical reporters of methyltransferases. Here we describe the facile, large-scale synthesis …
chemical reporters of methyltransferases. Here we describe the facile, large-scale synthesis …
From natural methylation to versatile alkylations using halide methyltransferases
Halide methyltransferases (HMTs) enable the enzymatic synthesis of S‐adenosyl‐l‐
methionine (SAM) from S‐adenosyl‐l‐homocysteine (SAH) and methyl iodide …
methionine (SAM) from S‐adenosyl‐l‐homocysteine (SAH) and methyl iodide …
Facile Chemoenzymatic Strategies for the Synthesis and Utilization of S‐Adenosyl‐L‐Methionine Analogues
A chemoenzymatic platform for the synthesis of S‐adenosyl‐l‐methionine (SAM) analogues
compatible with downstream SAM‐utilizing enzymes is reported. Forty‐four non‐native S/Se …
compatible with downstream SAM‐utilizing enzymes is reported. Forty‐four non‐native S/Se …
S-Adenosylmethionine: A Wolf in Sheep's Clothing, or a Rich Man's Adenosylcobalamin?
PA Frey, OT Magnusson - Chemical reviews, 2003 - ACS Publications
S-Adenosylmethionine (SAM) has long been known as the biological methylating agent,
because it serves as the methyl group donor in methylations of DNA, hormones …
because it serves as the methyl group donor in methylations of DNA, hormones …
Biomimetic S‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes**
L Gericke, D Mhaindarkar, LC Karst, S Jahn… - …, 2023 - Wiley Online Library
S‐Adenosylmethionine (SAM) is an enzyme cofactor involved in methylation, aminopropyl
transfer, and radical reactions. This versatility renders SAM‐dependent enzymes of great …
transfer, and radical reactions. This versatility renders SAM‐dependent enzymes of great …
Recent advances in methyltransferase biocatalysis
MR Bennett, SA Shepherd, VA Cronin… - Current Opinion in …, 2017 - Elsevier
Highlights•S-adenosyl methionine-dependent methyltransferases are ubiquitous in
nature.•Analogs of S-adenosyl methionine can be produced enzymatically.•Crystallography …
nature.•Analogs of S-adenosyl methionine can be produced enzymatically.•Crystallography …
A bicyclic S-adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocks
D Popadić, D Mhaindarkar, MHND Thai… - RSC Chemical …, 2021 - pubs.rsc.org
The ubiquitous cofactor S-adenosyl-L-methionine (SAM) is part of numerous biochemical
reactions in metabolism, epigenetics, and cancer development. As methylation usually …
reactions in metabolism, epigenetics, and cancer development. As methylation usually …