[HTML][HTML] NOV03 for dry eye disease associated with meibomian gland dysfunction: results of the randomized phase 3 GOBI study

J Tauber, GJ Berdy, DL Wirta, S Krösser, JL Vittitow… - Ophthalmology, 2023 - Elsevier
Objective To evaluate the efficacy and safety of NOV03 (perfluorohexyloctane) ophthalmic
drop in patients with dry eye disease (DED) associated with meibomian gland dysfunction …

[HTML][HTML] NOV03 for signs and symptoms of dry eye disease associated with meibomian gland dysfunction: the randomized phase 3 MOJAVE study

JD Sheppard, F Kurata, AT Epitropoulos… - American Journal of …, 2023 - Elsevier
Purpose To evaluate the efficacy and safety of NOV03 (perfluorohexyloctane) ophthalmic
drop for the treatment of signs and symptoms of dry eye disease (DED) associated with …

A randomized clinical study (SEECASE) to assess efficacy, safety, and tolerability of NOV03 for treatment of dry eye disease

J Tauber, DL Wirta, K Sall, PA Majmudar, D Willen… - Cornea, 2021 - journals.lww.com
Purpose: NOV03 has a unique dual mode of action to address dry eye disease (DED)
associated with meibomian gland dysfunction. SEECASE evaluated the efficacy, safety, and …

Dry eye disease associated with meibomian gland dysfunction: focus on tear film characteristics and the therapeutic landscape

JD Sheppard, KK Nichols - Ophthalmology and Therapy, 2023 - Springer
Meibomian gland dysfunction (MGD) is highly prevalent and is the leading cause of
evaporative dry eye disease (DED). MGD is characterized by a reduction in meibum …

Semifluorinated alkane eye drops for treatment of dry eye disease—a prospective, multicenter noninterventional study

P Steven, D Scherer, S Krösser, M Beckert… - Journal of Ocular …, 2015 - liebertpub.com
Purpose: Evaporation of the tear film is heavily discussed as one core reason for dry eye
disease (DED). Subsequently, new artificial tear products are developed that specifically …

[HTML][HTML] Efficacy and safety of OC-01 (varenicline solution) nasal spray on signs and symptoms of dry eye disease: the ONSET-2 phase 3 randomized trial

D Wirta, P Vollmer, J Paauw, KH Chiu, E Henry… - Ophthalmology, 2022 - Elsevier
Purpose To evaluate the efficacy and safety of OC-01 (varenicline solution) nasal spray for
treatment of patients with dry eye disease. Design Randomized, multicenter, double …

Efficacy and safety of diquafosol ophthalmic solution in patients with dry eye syndrome: a Japanese phase 2 clinical trial

Y Matsumoto, Y Ohashi, H Watanabe, K Tsubota… - Ophthalmology, 2012 - Elsevier
OBJECTIVE: To investigate the dose-dependent efficacy and safety of diquafosol ophthalmic
solution for the treatment of dry eye syndrome. DESIGN: Randomized, double-masked …

[HTML][HTML] A phase II randomized trial to evaluate the long-term (12-week) efficacy and safety of OC-01 (varenicline solution) nasal spray for dry eye disease: The …

H Quiroz-Mercado, E Hernandez-Quintela, KH Chiu… - The Ocular Surface, 2022 - Elsevier
Purpose Dry eye disease is characterized by loss of tear film stability. OC-01 (varenicline
solution) is a small-molecule nicotinic acetylcholine receptor agonist administered as a …

[HTML][HTML] Efficacy of topical ophthalmic drugs in the treatment of dry eye disease: A systematic literature review

EJ Holland, M Darvish, KK Nichols, L Jones… - The Ocular Surface, 2019 - Elsevier
Dry eye disease (DED) is a multifactorial and complex disease of the ocular surface, with a
high prevalence in adults. We systematically reviewed efficacy and safety data from …

Changing trends in the treatment of dry-eye disease

M Dogru, M Nakamura, J Shimazaki… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Dry eye is a visually disabling disease encountered in many countries with a
wide variation of treatment practices all over the world. On that front, the 2007 Report of the …