Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models

RL Hajnik, JA Plante, Y Liang, MG Alameh… - Science translational …, 2022 - science.org
Emergence of SARS-CoV-2 variants of concern (VOCs), including the highly transmissible
Omicron and Delta strains, has posed constant challenges to the current COVID-19 vaccines …

[PDF][PDF] mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

WF Garcia-Beltran, KJS Denis, A Hoelzemer, EC Lam… - Cell, 2022 - cell.com
Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.
1/B. 1.1. 529) harboring up to 36 mutations in spike protein, the target of neutralizing …

Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2

FG Özbay Kurt, A Lepper, C Gerhards… - Frontiers in …, 2022 - frontiersin.org
A gradual decay in humoral and cellular immune responses over time upon SAR1S-CoV-2
vaccination may cause a lack of protective immunity. We conducted a longitudinal analysis …

A booster dose of Delta× Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants

IJ Lee, CP Sun, PY Wu, YH Lan, IH Wang… - Journal of Biomedical …, 2022 - Springer
Background With the continuous emergence of new SARS-CoV-2 variants that feature
increased transmission and immune escape, there is an urgent demand for a better vaccine …

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant

F Zuo, H Abolhassani, L Du, A Piralla… - Nature …, 2022 - nature.com
The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and
the urgent need to study more efficient vaccination strategies. Here we observed that an …

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains

B Ying, B Whitener, LA VanBlargan… - Science translational …, 2021 - science.org
Although mRNA vaccines encoding the spike protein of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) prevent COVID-19, the emergence of new viral variants …

[PDF][PDF] A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or inactive virus COVID-19 vaccines

JME Lim, SK Hang, S Hariharaputran, A Chia… - Cell Reports …, 2022 - cell.com
Unlike mRNA vaccines based only on the spike protein, inactivated severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) vaccines should induce a diversified T cell …

Omicron-specific mRNA vaccine induced potent neutralizing antibody against Omicron but not other SARS-CoV-2 variants

IJ Lee, CP Sun, PY Wu, YH Lan, IH Wang, WC Liu… - BioRxiv, 2022 - biorxiv.org
The emerging SARS-CoV-2 variants of concern (VOC) harbor mutations associated with
increasing transmission and immune escape, hence undermine the effectiveness of current …

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

DW Hawman, K Meade-White, J Archer, SS Leventhal… - Elife, 2022 - elifesciences.org
Despite mass public health efforts, the SARS-CoV2 pandemic continues as of late 2021 with
resurgent case numbers in many parts of the world. The emergence of SARS-CoV2 variants …

Omicron: call for updated vaccines

X Li - Journal of medical virology, 2022 - Wiley Online Library
Abstract The Omicron SARS‐CoV‐2 variant was potentially generated from a chronically
infected COVID‐19 patient vaccinated with an messenger RNA (mRNA)‐or non‐mRNA …