It remains poorly understood about the regulation of gene and transposon transcription
during human early embryogenesis. Here, we report that broad H3K27ac domains are …

Epigenome reprogramming after fertilization enables transcriptionally quiescent maternal
and paternal chromatin to acquire a permissive state for subsequent zygotic genome …

Early embryonic development is characterized by dramatic changes in cell potency and
chromatin organization. The role of histone variants in the context of chromatin remodeling …

Background Transcription regulation in pluripotent embryonic stem (ES) cells is a complex
process that involves multitude of regulatory layers, one of which is post-translational …

In mammals, the time period that follows fertilization is characterized by extensive chromatin
remodeling, which enables epigenetic reprogramming of the gametes. Major changes in …

Compared with histone H3, acetylation of H4 tails has not been well studied, especially in
mammalian cells. Yet, H4K16 acetylation is of particular interest because of its ability to …

Early embryos undergo extensive epigenetic reprogramming to achieve gamete‐to‐embryo
transition, which involves the loading and removal of histone variant H2A. Z on chromatin …

Motivation During development of the mammalian embryo, histone modification H3K4me3
plays an important role in regulating gene expression and exhibits extensive reprograming …

Epigenetic modifications of the genome, such as covalent modification of histone residues,
ensure appropriate gene activation during pre-implantation development, and are probably …

Abstract H3K9me3-dependent heterochromatin is a major barrier of cell fate changes that
must be reprogrammed after fertilization. However, the molecular details of these events are …