Patients with systemic lupus erythematosus (SLE) present varied clinical manifestations,
posing a diagnostic challenge for physicians. Genetic factors substantially contribute to SLE …

Systemic lupus erythematosus (SLE) is a latent, insidious autoimmune disease, and with the
development of gene sequencing in recent years, our study aims to develop a gene-based …

Using three European and two Chinese genome-wide association studies (GWAS), we
investigated the performance of genetic risk scores (GRSs) for predicting the susceptibility …

Objective Systemic lupus erythematosus (SLE) is a highly heritable complex disorder with
heterogeneous clinical manifestations. In this study, we aimed to identify the genetic risk …

Objective Systemic lupus erythematosus (SLE) poses diagnostic challenges. We undertook
this study to evaluate the utility of a phenotype risk score (PheRS) and a genetic risk score …

ABSTRACT Introduction Systemic Lupus Erythematosus (SLE) is a complex multisystem
autoimmune disease with a wide range of signs and symptoms in affected individuals. The …

Background Rheumatoid arthritis (RA) and systemic lupus erythematous (SLE) are
autoimmune rheumatic diseases that share a complex genetic background and common …

Abstract Background Although the 2019 EULAR/ACR classification criteria for systemic
lupus erythematosus (SLE) has required at least a positive anti-nuclear antibody (ANA) titer …

Genome-wide association studies have identified risk loci for SLE, but a large proportion of
the genetic contribution to SLE still remains unexplained. To detect novel risk genes, and to …

Systemic lupus erythematosus (SLE) is a multi-systemic severe autoimmune disease which
results from the irreversible loss of self-tolerance and impaired molecular responses …