Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

Genomics data are now being generated at large quantities, of exquisite high resolution and
from single cells. They offer a unique opportunity to develop powerful machine learning …

Genome-scale analyses have allowed us to progress beyond studying gene expression at
the level of individual components of a given process by providing global information about …

Eukaryotic transcriptional regulation requires the integration of complex signals by the
transcriptional promoter. Distinct sequence elements, characteristic chromatin modifications …

Regulation of gene expression in eukaryotes is an extremely complex process. In this
review, we break down several critical steps, emphasizing new data and techniques that …

It is now established that Bcl11b specifies T cell fate. Here, we show that in developing T
cells, the Bcl11b enhancer repositioned from the lamina to the nuclear interior. Our search …

Transcriptional regulation is a critical biological process that allows the cell or an organism
to respond to a variety of intra-and extra-cellular signals, to define cell identity during …

The regions bound by sequence-specific transcription factors can be highly variable across
different cell types despite the static nature of the underlying genome sequence. This has …

Regulation of eukaryotic gene expression is far more complex than one might have
imagined 30 years ago. However, progress towards understanding gene regulatory …

Control of eukaryotic gene expression involves combinatorial interactions between
transcription factors and regulatory sequences in the genome. In addition, chromatin …