Steroid hormone receptors are ligand-binding transcription factors essential for mammalian
physiology. The androgen receptor (AR) binds androgens mediating gene expression for …

Androgen signaling through the androgen receptor (AR) directs gene expression in both
normal and prostate cancer cells. Androgen regulates multiple aspects of the AR life cycle …

Nuclear receptors, including the androgen receptor (AR), regulate target cell transcription
through interaction with auxiliary proteins to modify chromatin structure. We describe herein …

Formins are potent activators of actin filament assembly in the cytoplasm. In turn,
cytoplasmic actin polymerization can promote release of actin from megakaryocytic acute …

Abstract Activating transcription factor 3 (ATF3) is a common mediator of cellular stress
response signaling and is often aberrantly expressed in prostate cancer. We report here that …

Cell differentiation during spermatogenesis requires a proper actin dynamic, regulated by
several proteins, including formins. Disheveled-Associated-Activator of Morphogenesis1 …

Steroid receptors activate gene transcription by recruiting coactivators to initiate transcription
of their target genes. For most nuclear receptors, the ligand-dependent activation function …

During spermatogenesis, developing spermatids and preleptotene spermatocytes are
transported across the adluminal compartment and the blood-testis barrier (BTB) …

Many if not most proteins can, under certain conditions, change cellular compartments, such
as, for example, shuttling from the cytoplasm to the nucleus. Thus, many proteins may exert …

Androgens have key roles in normal physiology and in male sexual differentiation as well as
in pathological conditions such as prostate cancer. Androgens act through the androgen …