The use of alternative strategies for enhanced nanoparticle delivery to solid tumors
M Izci, C Maksoudian, BB Manshian… - Chemical …, 2021 - ACS Publications
Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …
decade. Classically, scientists have tried to improve NM delivery by employing passive or …
Tumor extravasation and infiltration as barriers of nanomedicine for high efficacy: The current status and transcytosis strategy
Nanotechnology-based drug delivery platforms have been explored for cancer treatments
and resulted in several nanomedicines in clinical uses and many in clinical trials. However …
and resulted in several nanomedicines in clinical uses and many in clinical trials. However …
Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology
Cancer nanotherapeutics are progressing at a steady rate; research and development in the
field has experienced an exponential growth since early 2000's. The path to the …
field has experienced an exponential growth since early 2000's. The path to the …
[HTML][HTML] Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target?
H Kobayashi, R Watanabe, PL Choyke - Theranostics, 2014 - ncbi.nlm.nih.gov
Nano-sized therapeutic agents have several advantages over low molecular weight agents
such as a larger loading capacity, the ability to protect the payload until delivery, more …
such as a larger loading capacity, the ability to protect the payload until delivery, more …
Strategies to improve the EPR effect: A mechanistic perspective and clinical translation
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …
their efficacy and to reduce their adverse effects. These efforts include the development of …
Active targeting schemes for nanoparticle systems in cancer therapeutics
JD Byrne, T Betancourt, L Brannon-Peppas - Advanced drug delivery …, 2008 - Elsevier
The objective of this review is to outline current major cancer targets for nanoparticle
systems and give insight into the direction of the field. The major targeting strategies that …
systems and give insight into the direction of the field. The major targeting strategies that …
Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms
Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …
Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunities
CL Waite, CM Roth - Critical Reviews™ in Biomedical …, 2012 - dl.begellhouse.com
Poor penetration of anticancer drags into solid tumors significantly limits their efficacy. This
phenomenon has long been observed for small-molecule chemotherapeutics, and it can be …
phenomenon has long been observed for small-molecule chemotherapeutics, and it can be …
Anticancer nanomedicine and tumor vascular permeability; Where is the missing link?
Anticancer nanomedicine was coined to describe anticancer delivery systems such as
polymer conjugates, liposomes, micelles, and metal nanoparticles. These anticancer …
polymer conjugates, liposomes, micelles, and metal nanoparticles. These anticancer …
Augmentation of the enhanced permeability and retention effect with nitric oxide–generating agents improves the therapeutic effects of nanomedicines
Enhanced permeability and retention (EPR) effect–based nanomedicine is a promising
strategy for successful anticancer therapy. The EPR effect is based on tumor blood flow …
strategy for successful anticancer therapy. The EPR effect is based on tumor blood flow …