OBJECTIVES: This study sought to identify monocyte alterations from septic patients after
hospital discharge by evaluating gene expression of inflammatory mediators and monocyte …

Background Failure of circulating monocytes for adequate cytokine production is a trait of
sepsis-induced immunosuppression; however, its duration and association with final …

Flow Cytometric Analysis of Monocytes Polarization and Reprogramming From Inflammatory
to Immunosuppressive Phase During Sepsis - PMC Back to Top Skip to main content NIH …

In a recent study conducted in a cohort of 52 septic patients, Monserrat and coworkers found
that profound failure of peripheral T cells to convert from a naïve phenotype to an activated …

Expanded abstract Citation Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton
AH, Bricker TL, Jarman SD 2nd, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green …

Impairment of the inflammatory-immune response is currently accepted as a hallmark of
severe sepsis even in the early stages of the disease. In this context, the alterations of the …

Background Sepsis is a leading cause of mortality and critical illness worldwide and is
associated with an increased mortality rate in the months following hospital discharge. The …

Background Sepsis is a life-threatening condition arising from an aberrant host response to
infection. Recent single-cell RNA sequencing investigations identified an immature bone …

Over the last decade it has become clear that the immunological response and clinical
course in sepsis patients is too complex to simply regard it as 'hyperinflammation-induced …

Introduction Recent models capturing the pathophysiology of sepsis and ex-vivo data from
patients are speculating about immunosuppression in the so-called late phase of sepsis …