The ketogenic diet as a treatment paradigm for diverse neurological disorders

CE Stafstrom, JM Rho - Frontiers in pharmacology, 2012 - frontiersin.org
Dietary and metabolic therapies have been attempted in a wide variety of neurological
diseases, including epilepsy, headache, neurotrauma, Alzheimer disease, Parkinson …

The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy

DN Ruskin, SA Masino - Frontiers in neuroscience, 2012 - frontiersin.org
A link between metabolism and brain function is clear. Since ancient times, epileptic
seizures were noted as treatable with fasting, and historical observations of the therapeutic …

[HTML][HTML] The mechanisms mediating the antiepileptic effects of the ketogenic diet, and potential opportunities for improvement with metabolism-altering drugs

NA Youngson, MJ Morris, JWO Ballard - Seizure, 2017 - Elsevier
The ketogenic diet (KD) is increasingly being used to treat patients with intractable epilepsy.
Despite decades of research, the reason for its success, when anticonvulsants have failed …

Anticonvulsant mechanisms of the ketogenic diet

KJ Bough, JM Rho - Epilepsia, 2007 - Wiley Online Library
The ketogenic diet (KD) is a broadly effective treatment for medically refractory epilepsy.
Despite nearly a century of use, the mechanisms underlying its clinical efficacy remain …

Therapeutic use of the ketogenic diet in refractory epilepsy: what we know and what still needs to be learned

IM Zarnowska - Nutrients, 2020 - mdpi.com
Ketogenic diet (KD) has been used to treat epilepsy for 100 years. It is a high-fat, low-
carbohydrate, and sufficient-protein-for-growth diet that mimics the metabolic changes …

How does the ketogenic diet induce anti-seizure effects?

JM Rho - Neuroscience letters, 2017 - Elsevier
The high-fat ketogenic diet (KD) is a remarkably effective treatment for medically intractable
epilepsy and has been part of the clinical armamentarium for nearly a century. However, the …

Metabolism and epilepsy: ketogenic diets as a homeostatic link

SA Masino, JM Rho - Brain research, 2019 - Elsevier
Metabolic dysfunction can underlie seizure disorders, and metabolism-based treatments can
afford seizure control and promote homeostasis. This relationship between metabolism and …

New insights into the mechanisms of the ketogenic diet

D Boison - Current opinion in neurology, 2017 - journals.lww.com
New insights into the mechanisms of the ketogenic diet : Current Opinion in Neurology New
insights into the mechanisms of the ketogenic diet : Current Opinion in Neurology Log in or …

Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations

H Zhu, D Bi, Y Zhang, C Kong, J Du, X Wu… - Signal transduction and …, 2022 - nature.com
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

Ketogenic diets: new advances for metabolism-based therapies

EH Kossoff, AL Hartman - Current opinion in neurology, 2012 - journals.lww.com
Ketogenic diets: new advances for metabolism-based therapies : Current Opinion in Neurology
Ketogenic diets: new advances for metabolism-based therapies : Current Opinion in Neurology …