Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Normal ageing is associated with diverse physiological changes in all organ systems but the
rate and extent of these changes vary markedly among individuals. One aspect of ageing …

Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …

Age is the single greatest risk factor for a wide range of diseases, and as the mean age of
human populations grows steadily older, the impact of this risk factor grows as well …

Organismal aging is driven by interconnected molecular changes encompassing internal
and extracellular factors. Combinational analysis of high-throughput 'multi-omics' datasets …

Age is the strongest risk factor for many diseases including neurodegenerative disorders,
coronary heart disease, type 2 diabetes and cancer. Due to increasing life expectancy and …

The aging process results in multiple traceable footprints, which can be quantified and used
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …

Human lifespan variation is mainly determined by environmental factors, whereas the
genetic contribution is 25–30% and expected to be polygenic. Two complementary fields go …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …