In the past, the blood-brain barrier (BBB) has been characterized mainly as a layer of
endothelial cells forming the vessel/capillary wall of the brain. More recently, the BBB is …

The blood–brain barrier (BBB) plays a crucial role in maintaining the specialized
microenvironment of the central nervous system (CNS). In aging, the stability of the BBB …

Insoluble pathogenic proteins accumulate along blood vessels in conditions of cerebral
amyloid angiopathy (CAA), exerting a toxic effect on vascular cells and impacting cerebral …

Intracellular accumulation of hyperphosphorylated misfolded tau proteins are found in many
neurodegenerative tauopathies, including Alzheimer's disease (AD). Tau pathology can …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most prevalent
cause of dementia. The main cerebral histological hallmarks are represented by …

The importance of vascular contributions to cognitive impairment and dementia (VCID)
associated with Alzheimer's disease (AD) and related neurodegenerative diseases is …

Introduction The blood-brain barrier (BBB) is damaged in tauopathies, including progressive
supranuclear palsy (PSP) and Alzheimer's disease (AD), which is thought to contribute to …

Microangiopathy, including proliferation of small diameter capillaries, increasing vessel
tortuosity, and increased capillary blockage by leukocytes, was previously observed in the …

Recent findings showed that vascular dysfunction is an integral part of Alzheimer's disease
pathology. Increased microvascular permeability is mainly associated with cerebrovascular …

Tauopathies represent a heterogeneous group of neurodegenerative disorders
characterized by abnormal deposition of the hyperphosphorylated microtubule-associated …