[HTML][HTML] Insights into the effects of mesenchymal stem cell-derived secretome in Parkinson's disease

M d'Angelo, A Cimini, V Castelli - International Journal of Molecular …, 2020 - mdpi.com
Mesenchymal stem cell (MSC)-derived secretome demonstrated therapeutic effects like
those reported after MSCs transplantation. MSC-derived secretome may avoid various side …

Cell secretome based approaches in Parkinson's disease regenerative medicine

CR Marques, A Marote… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: The available therapeutic strategies for Parkinson's disease (PD) rely only on
the amelioration of the symptomatology of the disease, lacking neuroprotection or …

[HTML][HTML] Bone marrow mesenchymal stem cells' secretome exerts neuroprotective effects in a Parkinson's disease rat model

B Mendes-Pinheiro, SI Anjo, B Manadas… - … in bioengineering and …, 2019 - frontiersin.org
Parkinson's disease (PD) is characterized by a selective loss of dopamine (DA) neurons in
the human midbrain causing motor dysfunctions. The exact mechanism behind …

[HTML][HTML] From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?

RC Silva, HS Domingues, AJ Salgado… - Neural Regeneration …, 2022 - journals.lww.com
Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide.
Clinically, it is characterized by severe motor complications caused by progressive …

Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?

FG Teixeira, MM Carvalho, N Sousa… - Cellular and Molecular …, 2013 - Springer
The low regeneration potential of the central nervous system (CNS) represents a challenge
for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have …

Impact of the secretome of human mesenchymal stem cells on brain structure and animal behavior in a rat model of Parkinson's disease

FG Teixeira, MM Carvalho… - Stem cells …, 2017 - academic.oup.com
Research in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated
therapeutic benefits are mainly due to their secretome, which has been proposed as a …

[HTML][HTML] Mesenchymal stem cells secretome: current trends and future challenges

FG Teixeira, AJ Salgado - Neural regeneration research, 2020 - journals.lww.com
Mesenchymal stem cells (MSCs) secretome: a good candidate for medical biotechnology?
Medical biotechnology is currently defined as the application of biotechnological tools for …

[HTML][HTML] Mesenchymal stromal cell-derived secretome-based therapy for neurodegenerative diseases: overview of clinical trials

M Ghasemi, E Roshandel, M Mohammadian… - Stem cell research & …, 2023 - Springer
Background Over the past few years, mesenchymal stromal cells (MSCs) have attracted a
great deal of scientific attention owing to their promising results in the treatment of incurable …

Secretome of undifferentiated neural progenitor cells induces histological and motor improvements in a rat model of Parkinson's disease

B Mendes-Pinheiro, FG Teixeira, SI Anjo… - Stem cells …, 2018 - academic.oup.com
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that
results from the death of dopamine (DA) neurons. Over recent years, differentiated or …

[HTML][HTML] Cell secretome: basic insights and therapeutic opportunities for CNS disorders

AG Pinho, JR Cibrão, NA Silva, S Monteiro… - Pharmaceuticals, 2020 - mdpi.com
Transplantation of stem cells, in particular mesenchymal stem cells (MSCs), stands as a
promising therapy for trauma, stroke or neurodegenerative conditions such as spinal cord or …