JAK inhibitors in dermatology: the promise of a new drug class
New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase–
signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling …
signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling …
Janus kinase inhibitors in dermatology: Part I. A comprehensive review
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular
signaling pathway is utilized by many proinflammatory molecules to mediate downstream …
signaling pathway is utilized by many proinflammatory molecules to mediate downstream …
JAK-inhibitors in dermatology: current evidence and future applications
P Ciechanowicz, A Rakowska, M Sikora… - Journal of …, 2019 - Taylor & Francis
The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway
is a ubiquitous intracellular signaling network. Selective JAK-inhibitors have anti …
is a ubiquitous intracellular signaling network. Selective JAK-inhibitors have anti …
Topical Janus kinase inhibitors: a review of applications in dermatology
AM Hosking, M Juhasz, NA Mesinkovska - Journal of the American …, 2018 - Elsevier
Background Janus kinase (JAK) inhibitors have attracted attention for their role in treating
inflammatory disorders. This new class of biologics has the potential to significantly affect the …
inflammatory disorders. This new class of biologics has the potential to significantly affect the …
[HTML][HTML] Targeting the Janus kinase family in autoimmune skin diseases
Autoimmune skin diseases are characterized by significant local and systemic inflammation
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …
[HTML][HTML] Emerging topical and systemic JAK inhibitors in dermatology
F Solimani, K Meier, K Ghoreschi - Frontiers in immunology, 2019 - frontiersin.org
Accumulating data on cellular and molecular pathways help to develop novel therapeutic
strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic …
strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic …
JAK‐inhibitors in dermatology–small molecules, big impact? Overview of the mechanism of action, previous study results and potential adverse effects
B Klein, R Treudler, JC Simon - JDDG: Journal der Deutschen …, 2022 - Wiley Online Library
Numerous chronic inflammatory skin diseases are associated with the release of
proinflammatory cytokines, which act via the intracellular JAK‐STAT pathway. JAK inhibitors …
proinflammatory cytokines, which act via the intracellular JAK‐STAT pathway. JAK inhibitors …
Janus kinase inhibitors in dermatology: Part II. A comprehensive review
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular
signaling pathway is implicated in the pathogenesis of a number of inflammatory …
signaling pathway is implicated in the pathogenesis of a number of inflammatory …
Emerging therapies for atopic dermatitis: JAK inhibitors
DG Cotter, D Schairer, L Eichenfield - Journal of the American Academy of …, 2018 - Elsevier
The Janus kinase–signal transducer and activator of transcription pathway is a conserved
master regulator of immunity and myeloproliferation. Advanced understanding of this …
master regulator of immunity and myeloproliferation. Advanced understanding of this …
Janus kinase inhibitors in dermatology: a systematic review
R Shreberk-Hassidim, Y Ramot, A Zlotogorski - Journal of the American …, 2017 - Elsevier
Background Janus kinase (JAK) inhibitors are emerging as a promising new treatment
modality for many inflammatory conditions. Objective Our aim was to systematically review …
modality for many inflammatory conditions. Objective Our aim was to systematically review …