Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
Stroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …
death worldwide—were conducted predominantly in populations of European ancestry …
Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations
Background and Purpose—The contribution of genetics to stroke risk, and whether this
differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis …
differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis …
Stroke genetics: discovery, insight into mechanisms, and clinical perspectives
S Debette, HS Markus - Circulation Research, 2022 - Am Heart Assoc
Stroke is the second leading cause of death worldwide and a complex, heterogeneous
condition. In this review, we provide an overview of the current knowledge on monogenic …
condition. In this review, we provide an overview of the current knowledge on monogenic …
Meta-analysis of genome-wide association studies identifies genetic risk factors for stroke in African Americans
Background and Purpose—The majority of genome-wide association studies (GWAS) of
stroke have focused on European-ancestry populations; however, none has been …
stroke have focused on European-ancestry populations; however, none has been …
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
Background and Purpose—Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …
several risk factors and each has a substantial heritability. We conducted a genome-wide …
Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies
G Chauhan, CR Arnold, AY Chu, M Fornage… - The Lancet …, 2016 - thelancet.com
Background Genetic determinants of stroke, the leading neurological cause of death and
disability, are poorly understood and have seldom been explored in the general population …
disability, are poorly understood and have seldom been explored in the general population …
Genetic risk factors for ischemic and hemorrhagic stroke
G Chauhan, S Debette - Current cardiology reports, 2016 - Springer
Understanding the genetic risk factors for stroke is an essential step to decipher the
underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize …
underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize …
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies
M Traylor, M Farrall, EG Holliday, C Sudlow… - The Lancet …, 2012 - thelancet.com
Background Various genome-wide association studies (GWAS) have been done in
ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have …
ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have …
Stroke genetics
HS Markus - Human molecular genetics, 2011 - academic.oup.com
Stroke represents an enormous health problem worldwide. It describes a clinical syndrome
which can be caused by a number of different pathologies, rather than a single disease …
which can be caused by a number of different pathologies, rather than a single disease …