Background: Activated fibroblasts are present in the injury response, tumorigenesis, fibrosis,
and inflammation in a variety of tissues and myriad disease types. Summary: During normal …

Fibroblasts are one of the most important and episodically active cell types in the kidney.
Under normal conditions, these cells provide a delicate collagenous matrix that partitions the …

Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

Renal fibrosis is a common consequence and often a central feature of all the progressive
renal diseases that lead to end-stage renal failure. In comparison to wound healing, during …

Pulmonary fibrosis refers to a heterogeneous group of disorders that scar the lung, most
often irreversibly. To date, there are limited effective treatments for these conditions, despite …

Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …

Chronic kidney diseases generally lead to renal fibrosis. Despite great progress having
been made in identifying molecular mediators of fibrosis, the mechanism that governs renal …

Renal fibrosis is the final common pathway for nearly all forms of kidney disease that
progress towards end-stage renal failure. As a sequel of inflammation and injury, humoral …

Epidemiological studies support a strong link between organ fibrosis and epithelial cancers.
Moreover, clinical and experimental investigations consistently indicate that these diseases …

Pathological scar formation, ie, fibrosis, is an integral part of the pathophysiological
mechanism underlying organ failure and disease progression in a multitude of pathologies …